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Clinical Trial Summary

This is an open, uncontrolled study of twenty-five chronic HCV infected patients carried out at Yassin Abdel Ghaffar Charity Center for Liver Disease and Research. The aim of this study is to investigate the safety & efficacy of combined therapy ledipasvir (LDV) and sofosbuvir (SOF) for treating HCV Genotype 4 in children aged 8 to 18. Due to previous positive results in other clinical studies of this drug it is expected that the drug will have high safety and high efficacy. Safety will be measured by checking for adverse effects, while efficacy will be measured by Real-Time Quantitative Polymerase Chain Reaction (qPCR) detecting viral nucleic acids in blood samples.


Clinical Trial Description

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Study Design


Related Conditions & MeSH terms


NCT number NCT03743727
Study type Interventional
Source Yassin Abdelghaffar Charity Center for Liver Disease and Research
Contact Mamdouh A. Ahmed
Phone 02-01221707770
Email dr.yassinabdelghaffar@gmail.com
Status Recruiting
Phase Phase 4
Start date August 1, 2018
Completion date June 30, 2019

See also
  Status Clinical Trial Phase
Completed NCT02593162 - A Study of Faldaprevir, Ribavirin and TD-6450 in Participants With Genotype 4 Hepatitis C Virus Infection Phase 2
Completed NCT03080415 - Treatment of Egyptian Hepatitis C Genotype 4 Infected Children (and Adolescents) With Combined Sofosbuvir & Daclatasvir Phase 3