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Cellular Immune Responses in the Liver in Chronic Hepatitis C (CHC) Patients

Hepatitis C, Chronic Clinical Trial

Official title:
Characterization of Cellular Immune Responses in the Liver in Patients With Chronic Hepatitis C Virus Infection

Clinical Trial Summary

In order to persist in the liver, HCV has numerous nonspecific and specific strategies to overcome the immunity of the host. The crucial step in the establishment of viral persistence and chronic hepatitis is the avoidance of specific antiviral cellular immune response in the liver. Treatment with pegylated interferon alpha (IFNα) in combination with ribavirin (RBV) is the standard therapy for chronic hepatitis C is. The response to IFNα / RBV therapy depends on the effective cellular antiviral immune response in the liver. The understanding of the interaction between HCV and cellular immune response is important for the effective use of existing diagnostic techniques, the Individual control and adjustment of the current therapeutic approaches and the development of future therapeutic and immunization strategies. In this study, the investigators want to investigate cellular Immune responses in the liver of HCV infected patients and characterize the influence of these immune responses to the response to IFNα / RBV therapy.

Clinical Trial Description

n/a

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01062659
Study type Observational
Source University of Ulm
Contact
Status Withdrawn
Phase N/A
Start date February 2010
Completion date March 2013
View Details
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