HBV Reactivation in Anti CD20 Treatment

Status Active, not recruiting

Clinical Trial Summary

The goal of this observational study is to test and describe the frequency of hepatitis B virus reactivation in patients who received anti-CD20 drugs for a wide variety of autoimmune and hemato-oncological diseases in order to find out whether a group of patients from a certain field was more sensitive to treatment in this respect than patients from other fields.

Clinical Trial Description

Hepatitis B virus(HBV) is the most common chronic virus worldwide. it causes an infection of the liver (hepatitis B) and it is transmitted from person to person through contact with virus-contaminated blood, through sexual intercourse, and vertically from mother to fetus. Anti CD20 drug or Rituximab is an anti-CD20 monoclonal antibody on the surface of B lymphocytes, which induces cell death (apoptosis) and thus causes depletion. The main side effects of rituximab are infectious and hypersensitivity reactions. It can also increase the chance of hepatitis B reactivation to the point of acute hepatitis. The information for this retrospective study will be collected from clalit health care's databases. The patients will be sorted according to the indications for which the treatment with anti-CD20 drugs was given in order to see the differences in the response to the drug in different groups of patient ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05768061
Study type	Observational
Source	HaEmek Medical Center, Israel
Contact
Status	Active, not recruiting
Phase
Start date	December 16, 2021
Completion date	December 2023

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