Optimized Treatment of Peginterferon Alfa 2a in Treatment Experienced

Status Recruiting

Clinical Trial Summary

Clinical Trial Description

Compared to TDF, peginterferon alfa 2a may has more therapeutic efficacy in hepatitis B surface antigen or e antigen seroconversion and anti-tumor occurrence in chronic hepatitis b patients. We design this study to compare the effectiveness and safety between the combination therapy of TDF and peg-IFN with TDF alone in NAs experienced patients with HBV related liver fibrosis. Especially the improvement of liver fibrosis and the occurrence of long-term end-stage liver disease such as cirrhosis, liver cancer, etc.

Main purpose: Comparing the improvement rate of liver fibrosis. Secondary purpose: Comparing the incidence of adverse events. Comparing the incidence of cirrhosis, hepatocellular carcinoma, and liver failure.

Comparing the rates of HBsAg and HBeAg serological conversion. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03957629
Study type	Interventional
Source	Third Affiliated Hospital, Sun Yat-Sen University
Contact	Shu Zhu, Master
Phone	+8615626477267
Email	zhush8@mail2.sysu.edu.cn
Status	Recruiting
Phase	N/A
Start date	November 6, 2019
Completion date	July 30, 2023

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Optimized Treatment of Peginterferon Alfa 2a in Treatment Experienced Patients With HBV Related Liver Fibrosis

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms