Hepatitis B Clinical Trial
Official title:
Antibody Persistence in Healthy South African Children After Primary Series and Booster Vaccination With an Investigational (DTaP-IPV-Hep B-PRP-T) or Control Vaccines
The purpose of this study is to evaluate the long term immunogenicity produced in children
by the investigational hexavalent vaccine (DTaP-IPV-Hep B-PRP-T) given in Study A3L15 (NCT
00362336).
Primary Objective: To describe the antibody long term persistence at 3.5 and 4.5 years of
age following a 3 dose primary series vaccination of either DTaP-IPV-Hep B-PRP-T or
CombAct-Hib™ + Oral poliovirus vaccine (OPV) + Engerix™ B vaccination at 6, 10 and 14 weeks
of age and a booster vaccination of DTaP-IPV-Hep B-PRP-T or CombAct-Hib™ + OPV at 15-18
months
All participants must have received the primary series of vaccinations and a booster
vaccination in Study A3L15 (NCT 00362336).
Participants will receive no vaccination in this study but will undergo immunologic
assessments at 3.5 and 4.5 years of age.
;
Observational Model: Cohort, Time Perspective: Prospective
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