Hepatitis B Vaccination Clinical Trial
Official title:
Mechanisms of Immunosenescence: A Single-Blinded Comparison of the Location of Vaccine Inoculum, Intramuscular Versus Subcutaneous Adipose Tissue, on the Immune Response of Healthy Elderly Adults to a Recombinant Hepatitis B Surface Antigen Vaccine (Recombivax-HB)
The first purpose of this study is to test the body's protective reaction (making antibodies)
to a licensed hepatitis B vaccine (Recombivax-HB) after it is injected either in the arm fat
or muscle. Hepatitis B virus is an important cause of liver disease in humans. More than 21%
of healthy adults over age 60 years demonstrate evidence of previous Hepatitis B infection
using a common blood test.
The second purpose of this study is to learn more information about other reasons (such as
body fat content, gene types, etc.), why older people respond less well than younger people
to vaccines. The Investigators will also learn more about the ability of certain white blood
cells, called T cells, to respond to protein signals in the blood. T cells do not seem to
respond as well to these protein signals as individuals age. The Investigators will compare
results to a younger group of volunteers who have also been vaccinated with hepatitis B
vaccine.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05787899 -
Hypothermia's Effect on Hepatitis B Vaccination
|
||
Completed |
NCT02959775 -
Immunogenicity of Hepatitis B Vaccination Among Drug Users
|
Phase 4 | |
Terminated |
NCT02166671 -
Immune Response to Hepatitis B Virus Booster Vaccination After 20-23 Years
|
N/A |