Hepatitis B, Chronic Clinical Trial
— CAESAROfficial title:
Continuation of Lamivudine Plus Adefovir Versus Switching to Entecavir Plus Adefovir in Adults With Chronic Hepatitis B Who Have Resistant Mutants to Lamivudine and Show Suboptimal Response to Combination of Lamivudine Plus Adefovir
Verified date | January 2014 |
Source | Asan Medical Center |
Contact | n/a |
Is FDA regulated | No |
Health authority | South Korea: Institutional Review Board |
Study type | Interventional |
The presence of persistent inadequate or suboptimal virologic response is a strong risk
factor for viral resistance and breakthrough and also for disease progression of chronic
hepatitis B, and thus, a change in therapy is required. The combination of entecavir (ETV)
and adefovir (ADV) is a promising treatment for patients with lamivudine (LAM)-resistance
who show suboptimal response to the combination of LAM and ADV.
In this randomized, open labeled trial,the investigators will compare the efficacy of
continuation of ADV plus LAM versus switch to ADV plus ETV in adults with LAM-resistant
chronic hepatitis B who shows suboptimal response to the combination treatment of ADV and
LAM.
Status | Completed |
Enrollment | 90 |
Est. completion date | September 2012 |
Est. primary completion date | July 2012 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 16 Years to 75 Years |
Eligibility |
Inclusion Criteria: 1. Male or female, 16 to 75 years of age 2. Compensated liver disease(Child-Pugh class A) 3. HBsAg positive at least 6 months or more 4. HBeAg positive or negative 5. Confirmation of Lamivudine-resistance HBV mutation anytime before the study 6. Patients with suboptimal response (HBV DNA > 2000 IU/mL despite combination of Adefovir [10 mg/day] plus Lamivudine [100 mg/day] for 6 months or more). Serum HBV DNA should be determined by the PCR assay at the local laboratory at screening for this study 7. Patient is ambulatory. 8. Patient is willing and able to comply with the study drug regimen and all other study requirements. 9. The patient is willing and able to provide written informed consent to participate in the study. Exclusion Criteria: 1. Patient has a history of hepatocellular carcinoma (HCC) or findings suggestive of possible HCC, such as suspicious foci on imaging studies or elevated serum alpha fetoprotein (AFP) levels. In patients with such findings, HCC should be ruled-out prior to randomizing the patient for the present study. 2. Patient previously received oral antiviral agent other than Lamivudine or Adefovir 3. Patient has received interferon or other immunomodulatory treatment for HBV infection within 12 months before screening for this study. 4. Patient has concomitant other chronic viral infection (HCV or HIV) 5. Patient has evidence of renal insufficiency defined as serum creatinine > 1.5 mg/dL 6. Patient has medical condition that requires use of systemic prednisolone or other immunosuppressive agent (including chemotherapeutic agent) 7. Patient is currently abusing alcohol or illicit drugs, or has a history of alcohol abuse or illicit substance abuse within the preceding two years. 8. Patient is pregnant or breastfeeding or willing to be pregnant 9. Patient has one or more additional known primary or secondary causes of liver disease, other than hepatitis B (e.g., alcoholism, autoimmune hepatitis, malignancy with hepatic involvement, hemochromatosis, alpha-1 antitrypsin deficiency, Wilson's Disease, other congenital or metabolic conditions affecting the liver, congestive heart failure or other severe cardiopulmonary disease, etc.). 10. A history of treated malignancy (other than hepatocellular carcinoma) is allowable if the patient's malignancy has been in complete remission, off chemotherapy and without additional surgical intervention, during the preceding three years. 11. Clinical signs of decompensated liver disease as indicated by any one of the following: - serum bilirubin > 3 mg/dL - prothrombin time > 6 seconds prolonged or INR >1.6 - serum albumin < 2.8 g/dL - History of ascites, variceal hemorrhage, or hepatic encephalopathy - Child-Pugh score =7 |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Korea, Republic of | Asan Medical Center | Seoul | the Meteropolis of Seoul |
Lead Sponsor | Collaborator |
---|---|
Asan Medical Center |
Korea, Republic of,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Complete Virologic Response (CVR, Serum HBV DNA Undetectable by PCR or Less Than 60 IU/mL) | at week 52 from randomization | No | |
Secondary | Reduction in Serum HBV DNA Levels | at week 52 and at week 104 from randomization | Yes | |
Secondary | Genotypic Resistance to ADV or ETV | at week 52 and at week 104 from randomization | Yes | |
Secondary | Normalization of ALT Level | at week 52 and at week 104 from randomization | Yes | |
Secondary | Complete Virologic Response (CVR, Serum HBV DNA Undetectable by PCR or Less Than 60 IU/mL) | at week 104 from randomization | No |
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