Metabolic Changes Induced by NMN in Healthy Subjects With Acute Binge

Status Active, not recruiting

Clinical Trial Summary

Clinical Trial Description

The goal of this double-blinded, randomized, crossover trial is to investigate the effects of NMN supplementation on liver function, liver fat content and lipid metabolism in healthy young subjects with acute binge drink. The main questions it aims to answer are: 1. if NMN administration could accelerate alcohol metabolism and alleviate hangover symptom; 2. if NMN administration could alleviate alcohol-induced liver injury and hepatic steatosis. Participants will be randomized into two groups (n=20), and take 4 NMN capsules (250mg/capsule) or 4 placebo capsules (maltodextrin), respectively. 15 minutes later, they are successively provided with same breakfast and then vodka with a dose of 1g/kg body weight. Venous blood are collected at 0h, 1h, 2h, 3h, 4h, 8h, 12h and 24h from each subject, respectively. In addition, nuclear magnetic resonance imaging (MRI) are taken at 0h, 4h and 24h after alcohol intake. After a 7-day washout period, volunteers are crossed over to another alternative group to receive the corresponding capsules and the test protocol repeats twice. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05882214
Study type	Interventional
Source	Zhejiang Chinese Medical University
Contact
Status	Active, not recruiting
Phase	N/A
Start date	March 1, 2024
Completion date	July 18, 2026

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05480696` - Soluble Fibre Supplementation in NAFLD	Phase 1
Completed	`NCT05124847` - TREating Pediatric Obesity	N/A
Recruiting	`NCT05499585` - Treating Pediatric NAFLD With Nutrition	N/A
Completed	`NCT03717935` - Oral Amino Acid Nutrition to Improve Glucose Excursions in PCOS	N/A
Active, not recruiting	`NCT02493153` - Hepatic Steatosis After Cholecystectomy	N/A
Active, not recruiting	`NCT05654051` - The SLIM LIVER Study	Phase 2
Completed	`NCT03334214` - Safety, Tolerability, and Pharmacodynamics of IONIS-DGAT2Rx in Adult Patients With Type 2 Diabetes	Phase 2
Enrolling by invitation	`NCT02816814` - Lacto-ovo-vegetarian Diet Riched in Omega-3 Fatty Acids in Menopausal Women	N/A
Active, not recruiting	`NCT03587727` - Hepatic Mitochondrial Function in Youth
Not yet recruiting	`NCT05935826` - Effect of Amino Acids on Hepatic Fat Content in Adolescents (AMINOS Study)	N/A
Not yet recruiting	`NCT06363617` - Implementation of the Fatty Liver Index in Primary Care	N/A
Recruiting	`NCT03142698` - Evaluation of 4 MRI Methods (PDFF 3, 6 and 11 Gradient Echoes and Spectroscopy) Compared to the Reference Method (Liver Biopsy) in Quantification of Hepatic Steatosis	N/A
Completed	`NCT00480922` - Effects of a Low Glycemic Load Diet on Fatty Liver in Children	N/A
Not yet recruiting	`NCT05871749` - Effects of Hepatic Fibrosis on Hepatic Steatosis Using the Ultrasound Attenuation Imaging in Chronic Hepatitis B
Recruiting	`NCT05897073` - Time-Restricted Eating, Exercise and Cardiometabolic Health in Obesity	N/A
Completed	`NCT03961516` - Glycemic Characterization and Pancreatic Imaging Correlates in Cystic Fibrosis
Completed	`NCT04180631` - Quantitative US for Hepatic Steatosis	N/A
Terminated	`NCT00845845` - Fish Oil and Diet for the Treatment of Non-Alcoholic Steatohepatitis (NASH)	Phase 2
Completed	`NCT02814240` - Hepatic Steatosis and Pituitary Gland Failure, Evaluation by Nuclear Magnetic Resonance (NMR) Imaging	N/A
Completed	`NCT05265026` - Aerobic Exercise Training in Patients With Chronic Hepatitis B and Hepatic Steatosis	N/A

Metabolic Changes Induced by NMN in Healthy Subjects With Acute Binge Drink — NMN-MeABD

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms