Effects of Coffee on Hepatic Steatosis Induced by a High Fructose Diet — COLIBRI  

Hepatic Steatosis Clinical Trial

Official title: Effects of Coffees With Various Compositions of Antioxidants on Hepatic Steatosis Induced by a High Fructose, Hypercaloric Diet

Status Completed

Clinical Trial Summary

This study will assess

• whether coffee consumption protects against fructose-induced hepatic steatosis in healthy humans

• whether the protective effect of coffee is dependent on it's antioxidant composition

Clinical Trial Description

Epidemiological studies suggest that coffee consumption improves glucose homeostasis in insulin resistant subjects. An increase in intrahepatic lipids (hepatic steatosis) is highly prevalent in patients with the metabolic syndrome and may be used as a marker of altered hepatic lipid metabolism. Such an increased hepatic lipids content can be experimentally produced in healthy humans by a 6-day high fructose diet.

The purpose of this study is to evaluate whether coffee prevents hepatic lipid deposition in healthy male subjects fed a fructose-rich hypercaloric diet. Both caffeine and antioxidants (yet unspecified) may be involved.. To sort out the role of caffeine and antioxidants, we will test 3 different soluble coffee, ie fully torrefied decaffeinated coffee , partially torrefied decaffeinated coffee, and partially torrefied caffeinated coffee. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Fatty Liver
• Hepatic Steatosis

• NCT number: NCT00827450
• Study type: Interventional
• Source: University of Lausanne
• Status: Completed
• Phase: N/A
• Start date: February 2009
• Completion date: March 2011