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Quantitative Determination of Brain Water Content in Patients During and After Hepatic Encepalopathy

Hepatic Encephalopathy Clinical Trial

Official title:
Quantitative Determination of Brain Water Content in Patients During and After Hepatic Encepalopathy Measured by MR

Clinical Trial Summary

There is increasing evidence that the pathophysiology of hepatic encephalopathy (HE) is tightly associated with low-grade cerebral edema. Uptake of ammonia in astrocytes leads to osmotic swelling caused by glutamine formation. Previous studies were performed in covert HE patients or used indirect methods.

Methods: The investigators wish to describes quantitative measurement of localized water content using MRI water mapping in a cohort of patients with cirrhosis during an episode of overt HE type C and again after recovery. Furthermore patients with cirrhosis and no history of HE and healthy subjects will be investigated as controls.

Clinical Trial Description

n/a

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02177708
Study type Observational
Source University of Aarhus
Contact
Status Recruiting
Phase N/A
Start date January 2014
Completion date December 2015
View Details
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