Colorectal Adenocarcinoma Clinical Trial
Official title:
Exhaustive Genetic and Immunological Characterization of Colon, Kidney and Liver Tumors to Define Potential Targets of Targeted and/or Immunomodulatory Therapies
Over the last 10 years, technological advances in molecular biology enabled a more accurate
genomic characterization of tumors. For each tumor location, this led to the identification
of subgroups with similar molecular characteristics. This identification allowed the
development of targeted therapies and thus to improve the patient prognosis. This molecular
characterization has also revealed the tumor heterogeneity. It may be the cause of treatment
resistance and therefore of relapses. Additionally, tumor cells are in constant dialogue
with their microenvironment composed of different immune or non immune cells. This
microenvironment is now targeted in cancer treatment.
To date, there are few studies that combine a deep genomic characterization of both tumor
and tumor microenvironment of the patient. Combining the two types of studies on the same
tumor should help to define new therapeutic targets and should allow a combination of
targeted and immunomodulatory therapies. To this end, our project is to conduct an
exhaustive integrated exploratory analysis at genomic, transcriptomic and immunological
levels of 3 tumor types (in colon, kidney and liver cancer).
The design consists in recruiting 50 patients per tumor location (colon, kidney, liver). For
colorectal and kidney cancers, a prospective enrollment will be done for patients who have
consented to the study. A retrospective enrollment will be done for patients with liver
cancer only and who have consented to a national biological resource center form with
genetic study approval.
The tumor samples will be taken during surgery. Blood and tumors samples will be taken as
part of the treatment.
In case of a accidental germline discovery a management by a genetic consulting will be
proposed.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT04094688 -
Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or Metastatic Colorectal Cancer
|
Phase 3 | |
| Active, not recruiting |
NCT04474470 -
A Study to Evaluate NT219 Alone and in Combination With ERBITUX® (Cetuximab) in Adults With Advanced Solid Tumors and Head and Neck Cancer
|
Phase 1/Phase 2 | |
| Recruiting |
NCT06050447 -
Factors Affecting the Results of Treatment of Patients With Colorectal Cancer
|
||
| Recruiting |
NCT05504252 -
METIMMOX-2: Metastatic pMMR/MSS Colorectal Cancer - Shaping Anti-Tumor Immunity by Oxaliplatin
|
Phase 2 | |
| Suspended |
NCT04108481 -
Immunotherapy With Y90-RadioEmbolization for Metastatic Colorectal Cancer
|
Phase 1/Phase 2 | |
| Completed |
NCT00597506 -
Expanded Cohort for Metastatic Colorectal Cancer (MCRC) Using Bevacizumab + Everolimus
|
Phase 2 | |
| Recruiting |
NCT05902988 -
A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer
|
Phase 1/Phase 2 | |
| Completed |
NCT05477836 -
Feasibility and Safety of MiWEndo-assisted Colonoscopy
|
N/A | |
| Recruiting |
NCT05620134 -
Study of JK08 in Patients With Unresectable Locally Advanced or Metastatic Cancer
|
Phase 1/Phase 2 | |
| Recruiting |
NCT03715933 -
Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas
|
Phase 1 | |
| Recruiting |
NCT04870879 -
Colorectal Metastasis and Liver Transplantation With Organs From Deceased Donors
|
N/A | |
| Recruiting |
NCT04773769 -
Study of Guanábana Leaves for The Treatment of Patients With Gastric, Gastroesophageal Junction, Pancreatic and Colorectal Adenocarcinomas; Hepatocellular Carcinoma, and Low Grade Lymphomas
|
N/A | |
| Recruiting |
NCT04739072 -
Minimal Residual Disease Assessment in Patients With Colorectal Cancer, the MiRDA-C Study
|
||
| Recruiting |
NCT06134440 -
ImmunoNutrition and Colorectal Adenocarcinoma Surgery - INCAS Study
|
N/A | |
| Withdrawn |
NCT03708536 -
Bevacizumab Plus Capecitabin vs S-1 as Maintenance Treatment Following First-line Chemotherapy in the Patients With Advanced Colorectal Adenocarcinoma
|
Phase 3 | |
| Withdrawn |
NCT02413853 -
Combination Chemotherapy and Bevacizumab With or Without PRI-724 in Treating Patients With Newly Diagnosed Metastatic Colorectal Cancer
|
Phase 2 | |
| Completed |
NCT00165217 -
Capecitabine and Thalidomide in Previously Treated Metastatic Colorectal Carcinoma
|
Phase 2 | |
| Active, not recruiting |
NCT04457284 -
Temozolomide, Cisplatin, and Nivolumab in People With Colorectal Cancer
|
Phase 2 | |
| Suspended |
NCT04111172 -
A Vaccine (Ad5.F35-hGCC-PADRE) for the Treatment of Gastrointestinal Adenocarcinoma
|
Phase 2 | |
| Not yet recruiting |
NCT06118658 -
Chemotherapy Sequential Tislelizumab After Radical Resection in Patients With dMMR/MSI-H or POLE/POLD1 Mutations
|
Phase 2 |