Hepatectomy Clinical Trial
Official title:
Open Liver Resection With or Without Vascular Inflow Occlusion: a Randomized Control Trial
This study aims to evaluate whether applying inflow vascular occlusion in modern liver
resection is associated with better clinical outcome.
Eligible patients are randomly assigned to the two surgical techniques: with or without the
application of inflow vascular occlusion.
Patients outcome including liver function recovery, operative time and blood loss are
compared.
Status | Completed |
Enrollment | 126 |
Est. completion date | August 2011 |
Est. primary completion date | May 2011 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Age > 18 years - Child-Pugh Class A or B Exclusion Criteria: - Informed consent not available - Presence of portal vein thrombosis, portal vein tumor thrombus, or previous portal vein embolisation - Presence of hepatic artery thrombosis, previous transarterial therapy like TACE, or transarterial internal radiation - When portal vein resection is anticipated - Emergency hepatectomy - Ruptured hepatocellular carcinoma - Rehepatectomy (repeated liver resection) - Adhesion or anatomical variation that preclude safe and successful application of Pringle maneuver - When concomitant bowel or bile duct resection is anticipated |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
China | Prince of Wales Hospital | Hong Kong |
Lead Sponsor | Collaborator |
---|---|
Chinese University of Hong Kong |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Operative blood loss | From skin incision to completion of operation | Yes | |
Primary | Operative time | From skin incision to completion of operation | No | |
Secondary | Operative morbidity and mortality | From date of operation to 30-day after operation | Yes | |
Secondary | Recovery of liver function | From date of operation to date of discharge | Yes |
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