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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT05937880
Other study ID # 2021-KY-002
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date January 1, 2023
Est. completion date June 30, 2027

Study information

Verified date July 2023
Source Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Contact Haiyan Wang, MD
Phone +8613560489257
Email wanghy78@mail.sysu.edu.cn
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This study conducted a prospective, multicenter, one-arm clinical trial on the combination of leflunomide and steroid therapy for refractory skin Henoch-Schonlein Purpura in children on the basis of ethical principles. A one-year follow-up was conducted to evaluate the changes in the main indicators (frequency of rash recurrence) and secondary indicators (proportion of kidney damage, proportion of joint involvement, T lymphocyte subpopulations, and inflammatory factors) before and after treatment, Exploring the safety and effectiveness of leflunomide in the treatment of refractory skin type HSP in children, it is expected that leflunomide combined with conventional treatment can improve the remission rate of HSP children's skin purpura and reduce HSP recurrence. The research results are expected to bring new treatment methods and strategies for this group of patients.


Recruitment information / eligibility

Status Recruiting
Enrollment 36
Est. completion date June 30, 2027
Est. primary completion date June 30, 2027
Accepts healthy volunteers No
Gender All
Age group 1 Year to 18 Years
Eligibility Inclusion Criteria: 1. Age ranges from 1 to 18 years old; 2. Patients meet the HSP diagnostic criteria; 3. Refractory skin type HSP: Rashes are dense and large in area, often treated with antibiotics, antihistamines, calcium supplements, and glucocorticoids (2 mg/kg/d) for 5 days. The rash does not subside or fresh rash still appears, and frequently repeated more than 3 times during hospitalization. 4. Parents or guardians agree to treatment and sign a written informed consent form. Exclusion Criteria: 1. Individuals who are allergic to leflunomide; 2. Concomitant severe underlying diseases (such as systemic malignancy, heart failure, liver and kidney failure, immune deficiency, severe infectious diseases, organ transplant surgery, or other current indications for emergency surgery); 3. Patients with other digestive system diseases; 4. Those who have previously used flumiphene in clinical trials; 5. Excluding purpura caused by drugs, infectious factors, and other autoimmune diseases. 6. Other situations where the researcher deems it inappropriate to participate in the study.

Study Design


Related Conditions & MeSH terms


Intervention

Drug:
Leflunomide
When patients appeared with rashes and treated with antibiotics, antihistamines, calcium supplements, and glucocorticoids (2 mg/kg/d) for 5 days. The rashes do not subside or fresh rash still appears, and it frequently repeats more than 3 times during hospitalization. Leflunomide would be administered

Locations

Country Name City State
China Sun Yat-sen Memorial Hospital, Sun Yat-sen University Guangzhou Guangdong

Sponsors (1)

Lead Sponsor Collaborator
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Country where clinical trial is conducted

China, 

Outcome

Type Measure Description Time frame Safety issue
Primary Rash frequency Rash frequency in a months 12 months
See also
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