Henoch Schönlein Purpura Clinical Trial
Official title:
Study of the Role of Regulator T Cells in the Pathophysiology of Childhood Henoch Schönlein Purpura
The primary objective of this study is to search for evidence of quantitative or functional defects in plasma regulatory T cells (Tregs) in pediatric patients with Henoch Schönlein Purpura (HSP) as compared to a control population.
The secondary questions/objectives for this study are:
A. During an inflammatory HSP flare, is there a quantitative and / or qualitative defect in
plasma Tregs? Are such blood anomalies real or are they due to a modification of the
distribution of theses cells to localized sites? B. In the asymptomatic phase, are there
quantitative or functional abnormalities among Tregs in subjects with HSP compared to healthy
control subjects? C. Are Treg abnormalities associated with modifications in other blood cell
lineages, including B cells secreting IgA and abnormally glycosylated IgA1, and secretion of
cytokines during acute relapses and during the asymptomatic phase? D. Can streptococcus or
other oral or digestive pathogens (bacterial or viral) (as suggested in other chronic
diseases such as rheumatoid arthritis ) provoke (via stimulation Th3) isotype commutation
towards secretion of IgA1 at the origin of HSP? Does HSP intestinal damage or imbalance of
the intestinal microbiota allow the translocation of intestinal microorganisms that sustain
this stimulation?
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