Intensive Care Unit Clinical Trial
Official title:
Evidence for SIRT1 Mediated HMGB1 Release From Kidney Cells in the Early Stages of Hemorrhagic Shock
It is reported that high mobility group box 1 (HMGB1), a non-histone nuclear protein, can serve as an alarmin with damage associated molecular patterns to activate immune responses in the early stages of hemorrhagic shock (HS). However, the origin of HMGB1 and how it is released following HS is poorly understood. In this study, we teased out this mechanism. We try to record the concentration of serum HMGB1 protein following HS in clinical patients.
The study was approved by the First People's Hospital of Chenzhou, Hunan, P.R. China. Consent was obtained from patients in their hospital course. Eighteen patients were enrolled for each group. In addition, Acute Physiological and Chronic Health Evaluation II (APACHE II) score was used to evaluate the severity and morbidity of HS patients Serial blood samples were collected at indicated time points on hospital admission for HS patients (0, 2, 4, 8, 24, and 72 h following HS). Levels of HMGB1 were detected by ELISA according to the kit manufacturer's instructions. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Not yet recruiting |
NCT04361032 -
Assessment of Efficacy and Safety of Tocilizumab Compared to DefeROxamine, Associated With Standards Treatments in COVID-19 (+) Patients Hospitalized In Intensive Care in Tunisia
|
Phase 3 | |
Completed |
NCT03520023 -
Critical Care and Palliative Care Medicine Together in the ICU
|
N/A | |
Completed |
NCT01169571 -
Study to Evaluate Hemodynamic Effect of Different Loading Doses of Precedex in Post-surgical Intensive Care Unit (ICU) Patients
|
N/A | |
Completed |
NCT01168128 -
PERFormance Enhancement of the Canadian Nutrition Guidelines by a Tailored Implementation Strategy: The PERFECTIS Study
|
N/A | |
Recruiting |
NCT05029167 -
REstrictive Versus LIberal Oxygen Strategy and Its Effect on Pulmonary Hypertension After Out-of-hospital Cardiac Arrest (RELIEPH-study)
|
N/A | |
Recruiting |
NCT06176807 -
Prediction of Acute Kidney Injury in Patients With Sepsis Using Venous Excess Ultrasound Score
|
||
Not yet recruiting |
NCT05367011 -
Therapeutic Monitoring of Antibiotics in Intensive Care Patients: a Cohort Study PopTDM-ICU
|
||
Recruiting |
NCT05056090 -
Effect of Prone Positioning on Mortality in Patients With Mild to Moderate Acute Respiratory Distress Syndrome.
|
N/A | |
Completed |
NCT04503135 -
Catheter Associated Asymptomatic Thrombosis in Intensive Care Unit
|
||
Completed |
NCT03983044 -
Comparison of Two Methods for Assessing Cough Capacity in Intensive Care Unit After Cardiac Surgery
|
||
Completed |
NCT05573659 -
Capillary Refill Time Calculated With a Video-assisted Method Has a Better Reproducibility Than Visual Method in Critically Ill Patients
|
N/A | |
Completed |
NCT06032169 -
Ankle Measurements of Arterial Pressure: Semi-recumbent or Horizontal Position.
|
||
Completed |
NCT04199273 -
Assessment of Human Diaphragm Strength by Magnetic and Electric Stimulation After Ultrasonography Phrenic Nerve Tracking
|
N/A | |
Recruiting |
NCT04353804 -
Returning to Everyday Tasks Utilizing Rehabilitation Networks-III (RETURN-III)
|
Phase 2 | |
Completed |
NCT03681626 -
Does Tracheal Suction During Extubation in Intensive Care Unit Decrease Functional Residual Capacity
|
N/A | |
Recruiting |
NCT04094428 -
Burden, Mortality and Supply Costs in Intensive Care Unit Patients
|
||
Completed |
NCT04014920 -
Non-invasive Ventilation Following Extubation (Prophylactic) to Prevent Extubation Failure in Critically Obese Patients
|
N/A | |
Completed |
NCT05131633 -
Regional Anaesthesia in Intensive Care Unit
|
||
Completed |
NCT06239987 -
The Effect of Care-oriented Practical Training on Nurses' Intensive and Critical Care Competency and HAIs Indicators
|
N/A | |
Completed |
NCT06121024 -
Long-term Outcomes of Post-intubation Tracheal Stenosis; 7-year Follow-up
|