Trauma Injury Clinical Trial
Official title:
Tranexamic Acid in Prehospital and In Hospital Civilian Trauma Care in Antifibrinolytic Therapy Study
The California Prehospital Antifibrinolytic Therapy (Cal-PAT) study seeks to evaluate the safety and efficacy of Tranexamic Acid (TXA) use in the civilian prehospital and in hospital setting in cases of traumatic hemorrhagic shock.
The Cal-PAT study is a multi-centered, prospective, observational cohort study. From March 2015 to July 2017, patients ≥ 18-years-old who sustained blunt or penetrating trauma with signs of hemorrhagic shock identified were considered for TXA treatment by first responders in the prehospital setting and physicians in hospital. A control group was formed of patients seen in the five years prior to data collection cessation (June 2012 to July 2017) at each receiving center who were not administered TXA. Control group patients were selected through propensity score matching based on gender, age, injury severity scores, and mechanism of injury. The primary outcome measured was mortality. Secondary outcomes measured included the total blood products transfused, the hospital and intensive care unit length of stay, and the incidence of known adverse events associated with TXA. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04567901 -
GNRI and Influence of Nutrition on the Mortality of Trauma Patients
|
||
Enrolling by invitation |
NCT05794165 -
Antithrombin to Improve Thromboprophylaxis and Reduce the Incidence of Trauma-Related Venous Thromboembolism
|
Phase 2 | |
Not yet recruiting |
NCT06326827 -
In'Oss™ (MBCP® Putty) Ortho
|
||
Recruiting |
NCT04403204 -
ICG Fluorescence Imaging in Post-traumatic Infection
|
||
Completed |
NCT04913402 -
Sufentanil Used by Paramedics to Treat Pain in Acute Trauma
|
||
Not yet recruiting |
NCT06070350 -
Massive Transfusion in Children-2: A Trial Examining Life Threatening Hemorrhage in Children
|
Phase 3 | |
Recruiting |
NCT05616130 -
Pathological Myeloid Activation After Sepsis and Trauma
|
||
Completed |
NCT05628519 -
Captain Sonar Impact on Trauma Patient Management
|
N/A | |
Recruiting |
NCT04907240 -
Observational GORE® VIABAHN® Endoprosthesis With PROPATEN Bioactive Surface Global Registry
|
||
Recruiting |
NCT06123104 -
Assessment of Automatic Tourniquets for Soldiers During Wartime
|
N/A | |
Recruiting |
NCT05865327 -
UltrasouNd-guided Percutaneous Intercostal Nerve Cryoneurolysis for Analgesia Following Traumatic Rib Fracture
|
N/A | |
Completed |
NCT05175872 -
Factors Affecting Mortality and Morbidity in Trauma Patients Followed in Intensive Care Unit
|
||
Not yet recruiting |
NCT04387305 -
Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children: An Efficacy Study
|
Phase 3 | |
Recruiting |
NCT04416412 -
ICG Fluorescence Imaging in Open Fracture Trauma Patients
|
||
Completed |
NCT04080479 -
Bolus Versus Continuous Enteral Tube Feeding
|
N/A | |
Completed |
NCT04030832 -
Reconstruction of Skin Substance Loss With "Micro-grafts" Obtained by Mechanical Disintegration
|
||
Active, not recruiting |
NCT06063434 -
Testing the Effectiveness of Night Shift, a Theory-based Customized Video Game
|
N/A | |
Not yet recruiting |
NCT04954768 -
Epidemiological Characteristics of Elderly Trauma Patients in Zhejiang Province and Development of Geriatric Trauma Short-term Mortality Prediction Model
|
||
Completed |
NCT04327895 -
Surgery in Context of Terrorist Attack : a Survey of French Surgeons
|
||
Completed |
NCT03888703 -
The Use of Fractional Ablative CO2 Laser vs Control on Acute Traumatic Injuries to Prevent Scar Formation
|
N/A |