Clinical Trials Logo
  1. Home
  2. Hemorrhagic Shock
  3. NCT03235921

Use of Nitroglycerine to Improve Signs of Poor Peripheral Perfusion in Patients With Traumatic Hemorrhagic Shock

Hemorrhagic Shock Clinical Trial

Official title:
Use of Nitroglycerine to Improve Signs of Poor Peripheral Perfusion in Patients With Traumatic Hemorrhagic Shock

Clinical Trial Summary

Hemorrhagic shock is a pathologic state in which intravascular volume and oxygen delivery are impaired. During circulatory failure associated with hypovolemia and low cardiac output, redistribution of blood flow caused by increased vasoconstriction results in decreased perfusion of the skin.

Skin temperature and capillary refill time has been advocated as a measure of peripheral perfusion.

Clinical Trial Description

Perfusion index (PI) is a non-invasive numerical value of peripheral perfusion obtained from pulse oximetry, it is an indicator of the pulse strength at the sensor site. The PI's values range from 0.2% for very weak pulse to 20% for extremely strong pulse according to patient's physiological conditions and monitoring sites.

Large increases in lactate (i.e. > 5 mmol/L) usually only occur due to hypoperfusion or muscle activity such as exercise or seizures.

This study will investigate the role of nitroglycerine patch in improving the peripheral perfusion in poly traumatized patient with hemorrhagic shock for the first time. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03235921
Study type Interventional
Source Assiut University
Contact medhat sayed, resident
Phone 01095105568
Email medhat_sayed_radwan@hotmail.com
Status Recruiting
Phase Phase 2
Start date March 2016
Completion date October 2017
View Details
See also
  Status Clinical Trial Phase
Completed NCT04149171 - Transfusion of Red Blood Cells, Tranexamic Acid and Fibrinogen Concentrate for Severe Trauma Hemorrhage Phase 3
Not yet recruiting NCT06070350 - Massive Transfusion in Children-2: A Trial Examining Life Threatening Hemorrhage in Children Phase 3
Not yet recruiting NCT02880163 - REVIVE: Reducing Exsanguination Via In-Vivo Expandable Foam N/A
Completed NCT02924792 - Sternal Intraosseous Transfusion of Autologous Whole Blood: A Comparison of Flow Rates and Degree of Hemolysis N/A
Terminated NCT00750997 - Hypertonic Modulation of Inflammation Following Injury N/A
Terminated NCT03477006 - Pragmatic Prehospital Group O Whole Blood Early Resuscitation Trial Phase 3
Not yet recruiting NCT04987411 - Detection of Exhaled Methane Levels in Hemorrhagic Shock
Recruiting NCT04610814 - Blood Transfusion by Boston MedFlight Registry
Completed NCT02071290 - Effect of Remote Ischemic Conditioning on Trauma Patients With Hemorrhagic Shock N/A
Completed NCT03535441 - HMGB1 Release From Hemorrhagic Shock Patients
Completed NCT03480555 - Replacing Protein Via Enteral Nutrition in a Stepwise Approach in Critically Ill Patients N/A
Completed NCT03402035 - Shock, Whole Blood, and Assessment of TBI S.W.A.T. (LITES TO 2)
Completed NCT05081063 - Low-Titer O Positive Whole Blood Versus Component Therapy for Emergent Transfusion in Trauma Patients Phase 3
Active, not recruiting NCT03469947 - California Prehospital and In Hospital Antifibrinolytic Therapy Via TXA Phase 3
Completed NCT01411852 - Field Trial of Hypotensive Versus Standard Resuscitation for Hemorrhagic Shock After Trauma Phase 2
Withdrawn NCT01221389 - Study Using Plasma for Patients Requiring Emergency Surgery Phase 4
Recruiting NCT03406598 - Bedside Visual Analysis of Sublingual Microcirculation in Shock Patients
Completed NCT00328133 - The Use of rFVIIa in Trauma Patients: A Multi-Center Case Registry N/A
Completed NCT00379522 - Vasopressin in Traumatic Hemorrhagic Shock Study Phase 2/Phase 3
Completed NCT00945542 - The Trauma- Formula-Driven Versus Lab-Guided Study (TRFL Study) Phase 1/Phase 2