Hemorrhagic Shock Clinical Trial
Official title:
Use of Nitroglycerine to Improve Signs of Poor Peripheral Perfusion in Patients With Traumatic Hemorrhagic Shock
Hemorrhagic shock is a pathologic state in which intravascular volume and oxygen delivery are
impaired. During circulatory failure associated with hypovolemia and low cardiac output,
redistribution of blood flow caused by increased vasoconstriction results in decreased
perfusion of the skin.
Skin temperature and capillary refill time has been advocated as a measure of peripheral
perfusion.
Perfusion index (PI) is a non-invasive numerical value of peripheral perfusion obtained from
pulse oximetry, it is an indicator of the pulse strength at the sensor site. The PI's values
range from 0.2% for very weak pulse to 20% for extremely strong pulse according to patient's
physiological conditions and monitoring sites.
Large increases in lactate (i.e. > 5 mmol/L) usually only occur due to hypoperfusion or
muscle activity such as exercise or seizures.
This study will investigate the role of nitroglycerine patch in improving the peripheral
perfusion in poly traumatized patient with hemorrhagic shock for the first time.
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