Tranexamic Acid in Breast Esthetic Surgery.

Status Recruiting

Clinical Trial Summary

The investigators prepared a novel tranexamic acid (TXA) study designed to estimate the quantity of blood loss in patients undergoing breast esthetic surgery. This study aims to quantify blood loss during abdominoplasty with and without TXA. The central hypothesis is that TXA administration reduces blood loss and fibrinolysis in breast esthetic surgery patients.

Clinical Trial Description

Tranexamic acid (TXA) treatment is increasingly emphasized in plastic surgery because TXA inhibits fibrinolysis. Increased clot stability offers the possibility of preventing blood loss (prevention) and mitigating ongoing hemorrhage. TXA therapy has been principally studied in populations; the results of studies in plastic surgery still need to be improved. Tranexamic acid is an antifibrinolytic agent that acts as a competitive inhibitor at the lysine binding sites of plasminogen and inhibits the ability of protease plasmin to cleave the fibrin clot. In large randomized controlled trials, it has been reported to be effective in decreasing perioperative blood loss in various circumstances, primarily involving trauma patients. The investigators designed a randomized placebo-controlled trial comparing TXA dosing before incision for breast esthetic surgery. The purpose is to quantify blood loss during plastic surgery with and without TXA. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05945680
Study type	Interventional
Source	Poznan University of Medical Sciences
Contact	Malgorzata Domagalska, Ph.D.
Phone	+48 608762068
Email	m.domagalska@icloud.com
Status	Recruiting
Phase	Phase 4
Start date	September 15, 2023
Completion date	December 1, 2024

View Details

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