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Hemorrhage clinical trials

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NCT ID: NCT00796900 Terminated - Hyperthermia Clinical Trials

Dantrolene for Treatment of Hyperthermia in Subarachnoidal Hemorrhage (SAH)

DTH1
Start date: May 2008
Phase: Phase 2/Phase 3
Study type: Interventional

Dantrolene is used to prevent hyperthermia in intensive care patients suffering from subarachnoidal hemorrhage.

NCT ID: NCT00779727 Terminated - Pregnancy Clinical Trials

Post-Cesarean Wound Drainage is Not Necessary in Women at Increased Risk of Hemorrhage

Start date: October 1999
Phase: Phase 4
Study type: Interventional

Randomized controlled trial assessing the benefit of cesarean wound drainage in pregnant women at increased risk of hemorrhage. The pregnant women at increased risk of hemorrhage were randomised in two groups. In one group 2 wound drainages were placed during the cesarean section, in the other group none. Outcome measures were difference between preoperative and postoperative hemoglobin, postoperative fever, cumulative opiate dose adjusted to body weight, length of stay and operation time. It is postulated that the pregnant women with increased risk of hemorrhage do not profit from the routine placement of wound drainages. - Trial with surgical intervention

NCT ID: NCT00774306 Terminated - Clinical trials for Subarachnoid Hemorrhage

Antiepileptic Drugs and Vascular Risk Markers

Start date: April 2009
Phase: N/A
Study type: Interventional

The purpose of this study is to determine if certain seizure medications raise levels of cholesterol and other blood components which could increase the risk of heart attacks and strokes.

NCT ID: NCT00770718 Terminated - Clinical trials for Intracranial Hemorrhage

Factor VII, Prothrombin Complex Concentrate, and Fresh Frozen Plasma in Warfarin-Related Intracranial Hemorrhage

Start date: April 2008
Phase: Phase 1
Study type: Interventional

The purpose of this dose-ranging pilot study is to compare Recombinant Activated Factor VII, Prothrombin Complex Concentrate and Fresh Frozen Plasma (each starting at low doses with escalation if necessary) for the reversal of warfarin in the setting of acute intracranial hemorrhage.

NCT ID: NCT00766961 Terminated - Bleeding Clinical Trials

TAE and Surgery in Patients With Peptic Ulcer Bleeding Uncontrolled by Endoscopic Therapy

Start date: April 2007
Phase: N/A
Study type: Interventional

The aim of the study is to compare the outcomes of trans-catheter arterial embolization (TAE) and surgery as salvage therapy of peptic ulcer bleeding after failed endoscopic therapy.

NCT ID: NCT00742313 Terminated - Bleeding Clinical Trials

Effect on Bleeding When Using FloSeal Matrix™ in Subjects Undergoing Endoscopic Vein Harvest (EVH)

Start date: June 2009
Phase: Phase 4
Study type: Interventional

This is a prospective, randomized trial to see in patients undergoing coronary artery bypass grafting and endoscopically-harvested greater saphenous vein, if using FloSeal Matrix in the endoscopically-harvested saphenous vein wound bed decreases bleeding and complications.

NCT ID: NCT00718328 Terminated - Clinical trials for Intracerebral Hemorrhage

Simvastatin For Intracerebral Hemorrhage Study

Start date: October 2008
Phase: Phase 2
Study type: Interventional

Study Objective: To analyze if statins are effective in ameliorating perihematomal edema evolution thereby reducing mortality and improving functional outcomes following spontaneous intracerebral hemorrhage (ICH).

NCT ID: NCT00665769 Terminated - Clinical trials for Intraventricular Hemorrhage

Physiological Disturbances Associated With Neonatal Intraventricular Hemorrhage

PhysDis
Start date: June 2008
Phase: N/A
Study type: Interventional

Annually, almost 5,000 extremely low birth weight (9 ounces to about 2 lbs) infants born in the US survive with severe bleeding in the brain (intraventricular hemorrhage); this devastating complication of prematurity is associated with many problems, including mental retardation, cerebral palsy, and learning disabilities, that result in profound individual and familial consequences. In addition, lifetime care costs for these severely affected infants born in a single year exceed $3 billion. The huge individual and societal costs underscore the need for developing care strategies that may limit severe bleeding in the brain of these tiny infants. The overall goal of our research is to evaluate disturbances of brain blood flow in these tiny infants in order to predict which of them are at highest risk and to develop better intensive care techniques that will limit severe brain injury. 1. Since most of these infants require ventilators (respirators) to survive, we will investigate how 2 different methods of ventilation affect brain injury. We believe that a new method of ventilation, allowing normal carbon dioxide levels, will normalize brain blood flow and lead to less bleeding in the brain. 2. We will also examine how treatment for low blood pressure in these infants may be associated with brain injury. We believe that most very premature infants with low blood pressure actually do worse if they are treated. We think that by allowing the infants to normalize blood pressure on their own will allow them to stabilize blood flow to the brain leading to less intraventricular hemorrhage. 3. In 10 premature infants with severe brain bleeding, we have developed a simple technique to identify intraventricular hemorrhage before it happens. Apparently, the heart rate of infants who eventually develop severe intraventricular hemorrhage is less variable than infants who do not develop this. We plan to test this method in a large group of infants, to be able to predict which infants are at highest risk of developing intraventricular hemorrhage and who could most benefit from interventions that would reduce disturbances of brain blood flow.

NCT ID: NCT00636597 Terminated - Occult GI Bleeding Clinical Trials

A Prospective Evaluation of Same Day Bidirectional Endoscopy for Occult Bleeding

Start date: April 2007
Phase: N/A
Study type: Observational

This study is a prospective evaluation of patients with occult (hidden) GI bleeding without iron deficiency. Such patients usually undergo a diagnostic colonoscopy as a standard of care. The study is aimed to determine any UGI-source of occult bleeding and to correlate UGI symptoms with findings. Therefore, EGD is being offered to such patients as part of research. We proposed to enroll 200 consecutive patients referred to our GI-unit for expedited diagnostic colonoscopy for positive FOBT.

NCT ID: NCT00635687 Terminated - Bleeding Clinical Trials

Transient Elastography and Variceal Bleeding

PROME
Start date: March 2008
Phase: N/A
Study type: Interventional

Transient elastography is a new non-invasive rapid and reproducible method, allowing evaluating liver fibrosis by measurement of liver stiffness. The aim of our study is to evaluate if the liver stiffness can predict the recurrence of upper variceal bleeding in cirrhotic patients hospitalized for variceal rupture.