Hemophilia Clinical Trial
Official title:
Bleeding Risk Evaluation in Haemophilia Patients Under Antiplatelet Therapies
Life expectancy of haemophilia patients (specially severe) has dramatically increase in the
last decades, which lead to the apparition of aging diseases such as cardiovascular disease,
with the potential bleeding risk of antiplatelet therapies and anticoagulants.
The primary endpoint of the study is to evaluate this bleeding risk in haemophilia patients
(all severity) with such treatment in comparison to non treated patients, according to the
number of bleeding events in the last year reported by the haemophilia patients under study
treatment (antiplatelet and anticoagulant) in comparison to haemophilia patients free of such
treatment. The main hypothesis is that antiplatelet and anticoagulant therapy can be safely
used in minor haemophilia patients but might lead to increase bleeding risk in other
haemophilia patients.
Secondary endpoint consist in:
- Evaluate the impact of know cardio-vascular risk in haemophilia patients (Odd ratios=OR)
- Evaluate the number of sever bleeding event in patient under study treatments compared
to the control group
- Evaluate the overall consumption of factor VIII or IX supply in patients under study
treatments compared to control group
- Estimate the stenosis relapse risk in haemophilia patients with arterial STENT
- Estimate the embolic risk of haemophilia patients with atrial fibrillation
Population description:
Haemophilia patients (man, all severity)
Age above 50 years, followed during the last 5 years in one of the study centre
n/a
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