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Clinical Trial Summary

Acquired hemophilia A is a rare condition of hemostasis secondary to the development of antibodies against factor VIII. This is a potentially serious pathology that can be life-threatening due to the major risk of bleeding caused by the sometimes drastic decrease in the level of circulating factor VIII. This pathology occurs overwhelmingly in elderly subjects or, more rarely, in young women, during the postpartum period. It appears idiopathic in 50% of cases and associated, for the other cases, with underlying pathologies such as autoimmune pathologies (rheumatoid arthritis and bullous pemphigoid in particular) and neoplasias, or with a particular circumstance represented by the post -partum. The association between this autoimmune pathology and its association with pathologies of the same type or with circumstances involving the immune system, suggests that common mechanisms could favor its emergence. This study therefore proposes to study lymphocyte populations and subpopulations as well as Myeloid-Derived Suppressor Cells and the cytokine profile, which are abnormal in a large part of autoimmune pathologies.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04805021
Study type Observational
Source Nantes University Hospital
Contact Marc Fouassier
Phone 02 40 08 40 49
Email marc.fouassier@chu-nantes.fr
Status Recruiting
Phase
Start date November 30, 2021
Completion date June 30, 2025

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