ASC618 Gene Therapy in Hemophilia A Patients

Status Recruiting

Clinical Trial Summary

Currently, hemophilia A patients are managed with prophylactic or on-demand replacement therapy with recombinant FVIII or alternative therapeutics. The major challenges of current treatment regimens, such as the short half-life of hemophilia therapeutics with the need for frequent IV injections, encourage the current efforts for gene transfer therapy. This study will evaluate the safety and preliminary efficacy of ASC618, an AAV vector encoding B-domain deleted codon-optimized human factor VIII under a synthetic liver-directed promoter

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Hemophilia A

Clinical Trial Details

NCT number	NCT04676048
Study type	Interventional
Source	ASC Therapeutics
Contact	Clinical Trial Manager, PhD
Phone	(408) 495-3891
Email	gil.gonen@asctherapeutics.com
Status	Recruiting
Phase	Phase 1/Phase 2
Start date	August 3, 2022
Completion date	December 2026

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