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Covalent Tolerance Induction to Factor VIII-Prediction of Inhibitors in Hemophilia

Hemophilia A Clinical Trial

Official title:
Covalent Tolerance Induction to Factor VIII-Prediction of Inhibitors in Hemophilia

Clinical Trial Summary

To correlate the Human Leukocyte Antigen type and genetic defect with hemophilia A.

Clinical Trial Description

One of the most serious complications of treatment in patients with hemophilia A or hemophilia B is the development of an inhibitor, which is an antibody that neutralizes the factor VIII or IX coagulant activity. Up to one fourth of patients with severe hemophilia A develop an inhibitor but at present it is not possible to predict which patients will develop such antibody. The ability to predict an inhibitor development at an individual level would greatly improve therapeutic approach to this serious problem ;

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00178607
Study type Observational
Source The University of Texas Health Science Center, Houston
Contact Madeline Cantini, BSN
Phone 713-500-8377
Email Madeline.Cantini@uth.tmc.edu
Status Recruiting
Phase N/A
Start date August 2002
Completion date June 2016
View Details
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