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Hemophilia A clinical trials

View clinical trials related to Hemophilia A.

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NCT ID: NCT03185897 Completed - Hemophilia A Clinical Trials

Global Epidemiologic Study of Preexisting Immunity to AAV in Adults With Severe Hemophilia

Start date: June 14, 2017
Phase:
Study type: Observational

Assess the seroprevalence of neutralizing antibodies (NAb) to AAV in adults with severe hemophilia A (coagulation factor VIII [FVIII] <1%) or moderately severe to severe hemophilia B (coagulation factor IX [FIX] ≤2%).

NCT ID: NCT03179748 Completed - Clinical trials for Congenital Bleeding Disorder

Study Investigating Novoeight®/NovoEight® (Turoctocog Alfa) in Mexican Haemophilia A Patients

Start date: June 20, 2018
Phase:
Study type: Observational

The trial is conducted in North America. The aim of the trial is to assess the safety of turoctocog alfa under conditions of routine clinical care in patients with haemophilia A in Mexico

NCT ID: NCT03169972 Completed - Hemophilia A Clinical Trials

ADYNOVATE Drug Use-Results Survey

Start date: April 12, 2017
Phase:
Study type: Observational

The purpose of this survey is to understand the following items in the actual clinical use of ADYNOVATE in patients: 1. Unexpected adverse drug reactions 2. Occurrence of adverse drug reactions in the actual clinical use 3. Factors that may affect safety and efficacy 4. Occurrence of Factor VIII inhibitor development in patients with coagulation factor VIII deficiency (hereinafter hemophilia A) 5. Safety and efficacy for hemophilia A patients who received routine prophylactic therapy and on-demand therapy

NCT ID: NCT03157154 Completed - Hemophilia Clinical Trials

Bleeding Risk Evaluation in Haemophilia Patients Under Antiplatelet Therapies

ERHEA
Start date: June 27, 2017
Phase:
Study type: Observational

Life expectancy of haemophilia patients (specially severe) has dramatically increase in the last decades, which lead to the apparition of aging diseases such as cardiovascular disease, with the potential bleeding risk of antiplatelet therapies and anticoagulants. The primary endpoint of the study is to evaluate this bleeding risk in haemophilia patients (all severity) with such treatment in comparison to non treated patients, according to the number of bleeding events in the last year reported by the haemophilia patients under study treatment (antiplatelet and anticoagulant) in comparison to haemophilia patients free of such treatment. The main hypothesis is that antiplatelet and anticoagulant therapy can be safely used in minor haemophilia patients but might lead to increase bleeding risk in other haemophilia patients. Secondary endpoint consist in: - Evaluate the impact of know cardio-vascular risk in haemophilia patients (Odd ratios=OR) - Evaluate the number of sever bleeding event in patient under study treatments compared to the control group - Evaluate the overall consumption of factor VIII or IX supply in patients under study treatments compared to control group - Estimate the stenosis relapse risk in haemophilia patients with arterial STENT - Estimate the embolic risk of haemophilia patients with atrial fibrillation Population description: Haemophilia patients (man, all severity) Age above 50 years, followed during the last 5 years in one of the study centre

NCT ID: NCT03103542 Completed - Hemophilia A Clinical Trials

Study of rFVIIIFc for Immune Tolerance Induction (ITI) in Haemophilia A Patients With Inhibitors Who Have Failed Previous ITI Therapies

ReITIrate
Start date: August 29, 2017
Phase: Phase 4
Study type: Interventional

The primary purpose of this study is to describe the outcome of Immune Tolerance Induction (ITI) treatment performed with rFVIIIFc within a timeframe of 60 weeks in patients with haemophilia A who have failed previous attempts at tolerization.

NCT ID: NCT03093480 Completed - Clinical trials for Hemophilia A With Inhibitors

A Study to Evaluate Efficacy of rFVIIIFc for Immune Tolerance Induction (ITI) in Severe Hemophilia A Participants With Inhibitors Undergoing the First ITI Treatment (verITI-8 Study)

Start date: December 8, 2017
Phase: Phase 4
Study type: Interventional

The primary purpose of this study was to describe the time to tolerization (i.e., ITI success) with rFVIIIFc in participants within a maximum of 48 weeks (12 months) of ITI treatment.

NCT ID: NCT03091751 Completed - Hemophilia B Clinical Trials

Efficacy and Safety of AlphaNine Versus BeneFIX in Patients With Severe Hereditary Haemophilia B

Start date: August 2005
Phase: Phase 2
Study type: Interventional

The goal of this non-randomized, multi-center study in subjects with severe hereditary haemophilia B was to determine and compare the pharmacokinetic and safety profiles of BeneFIX in subjects having had 2 prior pharmacokinetic assessments with AlphaNine.

NCT ID: NCT03075670 Completed - Clinical trials for Congenital Bleeding Disorder

A Trial Comparing Nonacog Beta Pegol (N9-GP) and ALPROLIX® in Patients With Haemophilia B

paradigmâ„¢7
Start date: March 7, 2017
Phase: Phase 1
Study type: Interventional

This trial is conducted in Europe and the United States of America. The aim of this trial is to compare the pharmacokinetics (the exposure of the trial drug in the body) of nonacog beta pegol (N9-GP) and ALPROLIX® in patients with haemophilia B.

NCT ID: NCT03055611 Completed - Haemophilia A Clinical Trials

A Study to Evaluate the Real-world Usage and Effectiveness of Elocta and Alprolix in Patients With Haemophilia A or B

PREVENT
Start date: May 9, 2017
Phase:
Study type: Observational

Elocta (rFVIIIFc) and Alprolix (rFIXFc) are recombinant extended half-life coagulation factor products. The purpose of this non-interventional study is to describe the real-world usage and effectiveness of Elocta and Alprolix in the prophylactic treatment of haemophilia A and B.

NCT ID: NCT03054662 Completed - Haemophilia Clinical Trials

Non Substitutive Strategies to Improve Haemophilia Care in Developing Countries. Experience in Ivory Coast.

Start date: January 16, 2017
Phase: N/A
Study type: Interventional

This study aims to make an inventory of the condition and care of patients with haemophilia and carriers for haemophilia in Ivory Coast and to promote the use non substitutive strategies that are not costly and available in Ivory Coast, to improve the management of haemophilia in this country. The purpose of this project is to evaluate the extent to which the active promotion of these various measures will improve the care of patients with haemophilia and carriers in Ivory Coast.