Hemophilia A, Congenital Clinical Trial
Official title:
Descriptive Pilot Study of Monitoring of Physical Activity in Adult Patients With Haemophilia A Arthropathy by Means of Accelerometry, Image Tests and Physical Condition Parameters. Benefits Associated With That Monitoring"
Research Question: Does an specific and pre-defined physical exercise prescribed by a
specialist provide any benefit on haemophilic arthropathy, the quality of life or the
physical condition of patients with haemophilia A and haemophilic arthropathy? Does adherence
to physical exercise improve when monitoring patients with an accelerometer? Do compliant
patients find higher benefit on haemophilic arthropathy, quality of life or the physical
condition than non-compliant patients?
Primary Endpoint: Assess in patients with haemophilia A and haemophilic arthropathy if a
prescribed and specific physical exercise monitored by an accelerometer is producing any
change in the following domains: progress of haemophilic arthropathy; health-related quality
of life; physical condition.
Secondary Endpoints: Evaluate the adherence to physical exercise in patients with haemophilia
A and haemophilic arthropathy by means of accelerometry, and asses if compliant patients
achieve higher improvement in these 3 domains than non-complaint patients.
Specific details of Treatment/Intervention:
Physical exercises that are part of the specific medical program prescribed for each patient.
The exercise program for each patient will depend of the haemophilic arthropathy, the level
of physical condition and the preferences of the patient.
Monitoring of physical activity will be made by means of accelerometers. Its use does not
alter the daily activities and does not require any change of the patients' individual
habits. The assessment of the patients' cardiovascular condition will be made using pulse
monitors. Normal examinations in clinical practice will be revised as well as those specific
to each patient reference health centre, muscle strength and joint use testing which will be
validated with force measurement devices. Assess by means of an ultrasound system the
baseline situation of the joints used for daily activities for injury control. Determine the
likelihood of fracture and assess the bone quality by means of densitometry. Thermal cameras
will allow to analyse the characteristics of Joint inflammation. It may be suitable for
bleeding evolution control. Measurements given by densitometers will allows to determine the
state of bones of the participants in the study (osteoporosis measurement). Number of
bleeding events/hemarthrosis during the period of study. Determine the activity of
hemarthros/synovitis using thermal images.
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