Hemopathy Clinical Trial
Official title:
Evaluation of a Kit for the Prediction of the Risk of Graft Versus Host Disease
This study is a proof of concept that will assess the Predictor's kit performances. The test
will be performed by several technicians, in immunological laboratories of several sites in
France.
In this study, "couples" of donor / recipient in the frame of a graft of CSH will be
included.
The Hematopoietic Stem Cell (HSC) graft is the only curative treatment for lots of
hematologic diseases, malignant or not, particularly leukemias.
The acute Graft versus Host (aGvH) reaction is the most frequent complication, and could
concern until 50% of recipients. It is mainly linked to immune characteristics of the donor
which will act versus the graft recipient.
There is a huge need of a technology that could predict the risk of aGvH, especially in order
to select a donor in case of several possibilities, in order to reduce morbidity and
mortality of graft.
The Predictor' kit allows to predict acute and severe forms of Graft versus Host disease
before the graft of peripheral hematological stem cells, by the assesment of iNKT cells
expansion.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT02065297 -
Quantitative and Functional Study of TH17 Lymphocytes in Horton's Disease (HD)
|
||
Recruiting |
NCT02260739 -
Sequential Analysis in Patients With an Hemopathy
|
N/A | |
Recruiting |
NCT03102905 -
Prevalence of Replication of Human Herpes Virus 6 (HHV6) in Blood and Skin During Exanthemia, in Patients With Hemopathy. Is There a Correlation With the Etiology of the Exanthema?
|
N/A | |
Not yet recruiting |
NCT06369389 -
Real-life Management of Patients Eligible for CAR-T Cell Therapy
|