Comparison of the Automatized and the Optimized Carbon Monoxid Rebreathing Protocol

Hemoglobins Clinical Trial

Official title: Comparison of the Automatized and the Optimized Carbon Monoxid Rebreathing Protocol Determining Hemoglobinmass With Capillary and Venous Blood Sampling

Status Recruiting

Clinical Trial Summary

The aim of this study is the comparison of two measurement protocols determining hemoglobin mass with two different blood sampling strategies.Both protocols are based on the principle of the carbonmonoxid (CO) rebreathing method. During this measurement, CO is inhaled for a specific time period by the subject in a closed circuit and it is used as a marker to tag circulating hemoglobin.

Clinical Trial Description

The optimized CO rebreathing protocol (oCO) will be compared against the automatized CO rebreathing protocol (aCO). Although theses two protocols using the same method, they show some relevant differences.

The oCO use a 2 minutes rebreathing period in a seated position and capillary blood is taken. The aCO use a 10 minutes rebreathing period in a supine position and venous blood samples are taken.

It is essential to know to what extent the aCO with capillary or venous blood sampling with different rebreathing time and position compared to oCO will influence the provided hemoglobin mass values. It is important to ensure the comparability of formely hemoglobinmass data measured using oCO with hemoglobinmass data measured using aCO for scientific research. ;

Related Conditions & MeSH terms

• Hemoglobins

• NCT number: NCT04189250
• Study type: Interventional
• Source: Swiss Federal Institute of Sport Magglingen
• Contact: Jon Wehrlin, Dr. scient., MSc.
• Phone: +41 58 467 61 25
• Email: jon.wehrlin@baspo.admin.ch
• Status: Recruiting
• Phase: N/A
• Start date: January 20, 2020
• Completion date: August 1, 2020