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Clinical Trial Summary

Remimazolam is a recently developed ultra-short agonist acting at the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)A receptor. Remimazolam has a combination of the hemodynamic stability of benzodiazepines and the advantages of propofol, such as rapid onset, short duration of action, and improved controllability. A recent study showed that the efficacy of two induction doses of remimazolam (6 and 12 mg/kg/h) as a sedative for general anesthesia was not inferior to propofol (2.0-2.5 mg/kg), and hemodynamically more stable. On the other hand, a study on the emergence time and quality between propofol and remimazolam showed inconsistent results. The purpose of this study is to compare remimazolam to propofol on the intraoperative hemodynamic changes and recovery profiles, when used in combination with remifentanil in elderly patients undergoing general anesthesia.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05201300
Study type Interventional
Source Ajou University School of Medicine
Contact Jong Yeop Kim, M.D., Ph.D.
Phone +82312195574
Email [email protected]
Status Not yet recruiting
Phase N/A
Start date March 2, 2022
Completion date December 31, 2022

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