Hemodynamic Repercussions in Different Therapeutic Positions in Premature Newborn

Hemodynamics Clinical Trial

Official title:

Hemodynamic Repercussions in Different Therapeutic Positions in Premature Newborn Under Invasive Mechanical Ventilation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05145114
• Other study ID #: 3.983.789
• Status: Completed
• Phase: N/A
• Start date: May 6, 2020
• Est. completion date: January 15, 2021

Study information

• Verified date: December 2021
• Source: Amazon University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Introduction: Prematurity refers to babies born before 37 weeks of gestation that through technological advances survival is increasing, since most of them are referred to the Neonatal Intensive Care Unit (NICU). Hemodynamic monitoring is of fundamental importance in the care provided to critically ill patients and mechanical ventilation (MV) is often used for the recovery and maintenance of newborns, especially premature infants with any pathology that causes cardiorespiratory failure. Considering this, it is necessary to look for ways to treat these newborns (NB), being the therapeutic positioning one of the simplest and most fundamental to reduce the consequences of the mechanical advantages of the respiratory system of newborns. Objective: To evaluate the hemodynamic repercussions in the various therapeutic positions in premature newborns under invasive mechanical ventilation. Method: A field study to be conducted will be randomized on an experimental, quantitative and descriptive character. It will be developed at the Santa Casa de Misericórdia do Pará Foundation (FSCMPa), in the Neonatal Intensive Care Unit. The population to be evaluated will be preterm infants with gestational age ≤37 weeks, on invasive mechanical ventilation, with no congenital malformations, with the diagnosis of intracranial hemorrhage and that those responsible, after being informed, authorized to participate in the research. Being excluded the preterm infants without legal companion, who are affected by any unfavorable clinical condition, which makes the change of unfeasible position, children with neuromuscular diseases, tracheostomized. A sample will be randomly selected in groups: Prono Group (GP), Supine Group (GS) and Lateral Decubitus Group (GDL). The decubitus to be adopted for each research subject will then be registered by the researcher in a specific form, recording as respiratory cardiological responses: respiratory rate (RR), heart rate (HR) and peripheral oxygen saturation (SPO2), temperature (T) and pressure blood pressure (BP). Such clinical responses will be noted prior to NB positioning, then positioned according to the group to which they will belong for 30 minutes, and then there will be another selection of vital signs.

Description:

The present field study to be carried out will be controlled clinical trial, randomized, experimental, quantitative and analytical. The research will be carried out in accordance with the ethical aspects recommended in the Declaration of Helsinki and Nuremberg Code, and by the research standards that may involve human beings of the National Health Council. Parents and guardians of premature newborns eligible for the survey will be invited to consent to the participation of newborns in the survey, in which the purpose, objectives and procedures of the research will be explained, requesting the signature of the Informed Consent Form and Informed and the Informed Consent Term.Then, access to data related to the newborn's medical record will be performed through the presentation of the Data Use Commitment Term. The sample will be randomly separated into groups: Prone Group, Supine Group and Lateral Decubitus Group. The decubitus to be adopted for each research subject will then be registered by the researcher in a specific form that will contain the following information: identification, gender, Apgar in the first and fifth minutes, GA, weight, use of surfactant and amount of doses, time of use of mechanical ventilation, length of hospital stay and others, with this information being obtained from the newborn's medical record, this step will provide data that will characterize the sample. For data acquisition via medical records, the researcher will submit the consent form for data use. The most used physiological parameters are vital signs, such as heart rate and percutaneous oxygen saturation, as they are the most easily observed responses. The most used physiological parameters are vital signs, such as heart rate and percutaneous oxygen saturation, as they are the most easily observed responses. This is due to the fact that babies who need intensive care are usually under these assessments constantly by pulse oximeters and because they have been the best scientifically validated among the physiological responses. The vital signs of heart rate (HR), often respiratory rate (RR) and blood pressure (BP), can be influenced by the infant 's age and health condition. Peripheral oxygen saturation may have its results altered by the baby's behavioral state and pulmonary conditions. The assessment of HR and RR, indirectly, may reflect respiratory discomfort, it is common to observe tachypnea and some patients present tachycardia for not accepting or tolerating the positioning they are submitted. To record the monitoring of cardiorespiratory physiological responses, an interval of 2 hours after the diet will be respected so that there are no complications during the procedure. The respiratory rate (RR) will be collected for this, the thoracic incursions of the patients will be observed for one minute, counted on a digital clock, and to measure the heart rate (HR) and peripheral oxygen saturation, a pulse oximeter will be used, provided by the institution , positioned on the newborn's foot. Axillary temperature will also be measured with a thermometer specific to each NB and blood pressure with a device from the institution.

Such clinical responses will be noted before the positioning of the NB, then participants will be positioned according to the group they belong to for 30 minutes, and then there will be a new verification of vital signs. During the time they are positioned, the RN will be asked not to receive routine procedures from the NICU or any stimulation by the health team. Only in cases that require urgent intervention. Being evaluated 1 times a day in the morning shift for two weeks. The collected data will be stored in Microsoft Excel® spreadsheets , which will serve to perform a simple descriptive statistics that will be presented in percentages, arranged in graphs and tables. Statistical analysis will be based on the use of statistical tests that best fit the study proposal through the Biostat ® statistical package . In order to know the profile of the data, the Shapiro-Wilk test will be applied to verify whether the data under analysis presented normality. To compare the mean values of the data, the ANOVA test will be performed, followed by the Newman-Keuls multiple comparison test for the variables: heart rate, respiratory rate, oxygen saturation and the Studen t test for the variables: blood pressure and axillary temperature. In all tests, the level for rejecting the null hypothesis will be set at 5% (p<0.05).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: January 15, 2021
• Est. primary completion date: October 1, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A to 37 Weeks

Eligibility

Inclusion Criteria:

• PTNB with GA =37 weeks

• In ventilation invasive mechanics

• With absence of congenital malformations

• With absence a diagnosis of intracranial hemorrhage

• That the guardians after being informed, authorized to participate in the research

Exclusion Criteria:

• PTNB without a legal companion

• Who are affected by some unfavorable clinical condition that makes it impossible to change position

• Children with neuromuscular diseases

• Tracheostomized

Related Conditions & MeSH terms

• Hemodynamics
• Premature Birth

Intervention

Procedure:
• THERAPEUTIC POSITIONS
Therapeutic positioning includes placing infants in prone (prone), supine, side (lateral) decubitus, using restraint devices to provide support, reassurance and physiological stability.

Locations

Country	Name	City	State
Brazil	Paulo Eduardo Santos Avila	Belém	Pará

Sponsors (1)

Lead Sponsor	Collaborator
Amazon University

Country where clinical trial is conducted

Brazil, 

References & Publications (6)

DE CARVALHO MORSCH, A. L. B. et al. Análise das repercussões clínicas da aplicação da posição prona em prematuros sem doença pulmonar. ERSPECTIVA, Erechim. v. 42, Edição Especial, p. 07-14, março, 2018.

DE CORDOBA LANZA, F.; BARCELLOS, P.G.; DAL CORSO, S. Benefícios do decúbito ventral associado ao CPAP em recém-nascidos prematuros. Fisioterapia e Pesquisa, v. 19, n. 2, p. 135-140, 2012.

DE SÁ, F. E. et al. Estudo sobre os efeitos fisiológicos da técnica de aumento do fluxo expiratório lento em prematuros. Fisioterapia & Saúde Funcional, v. 1, n. 1, p. 16-21, 2012.

Hough JL, Johnston L, Brauer SG, Woodgate PG, Pham TM, Schibler A. Effect of body position on ventilation distribution in preterm infants on continuous positive airway pressure. Pediatr Crit Care Med. 2012 Jul;13(4):446-51. doi: 10.1097/PCC.0b013e31822f18 — View Citation

Oliveira TG, Rego MA, Pereira NC, Vaz LO, França DC, Vieira DS, Parreira VF. Prone position and reduced thoracoabdominal asynchrony in preterm newborns. J Pediatr (Rio J). 2009 Sep-Oct;85(5):443-8. doi: 10.2223/JPED.1932. English, Portuguese. — View Citation

Ramada NC, Almeida Fde A, Cunha ML. Therapeutic touch: influence on vital signs of newborns. Einstein (Sao Paulo). 2013 Dec;11(4):421-5. English, Portuguese. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Vital sign of respiratory rate (rpm) will be measured before and after in different therapeutic positions of premature newborns under invasive mechanical ventilation.	The respiratory rate (irpm) will be checked on the mechanical ventilator, noted before the positioning of premature newborns. Next, the newborns will be positioned according to the group and then there will be a recheck of the respiratory rate.	Each newborn will be evaluated for only two weeks, being evaluated once a day, in the morning shift.
Primary	Heart rate vital sign (bpm) will be measured before and after at different therapeutic positions of premature newborns under invasive mechanical ventilation.	The heart rate (bpm) will be checked on the multiparametric vital signs monitor with a value verified by means of electrodes adhered to the patients' chest, noted before the positioning of the premature newborns. Next, the newborns will be positioned according to the group and then there will be a new heart rate check.	Each newborn will be evaluated for only two weeks, being evaluated once a day, in the morning shift.
Primary	Vital sign of peripheral oxygen saturation (percentage) will be measured before and after in different therapeutic positions of premature newborns under invasive mechanical ventilation.	Peripheral oxygen saturation (percentage) will be verified in the multiparametric vital signs monitor with a value verified through the finger oximeter, noted before the positioning of the premature newborns. Next, the newborns will be positioned according to the group and then there will be a new check for peripheral oxygen saturation.	Each newborn will be evaluated for only two weeks, being evaluated once a day, in the morning shift.
Primary	Vital sign of temperature (degree Celsius) will be measured before and after in different therapeutic positions of preterm newborns under invasive mechanical ventilation.	The temperature (degree Celsius) will be checked in the multiparametric vital signs monitor with a value verified by means of a sensor attached to the patient's axillary region, noted before the positioning of the premature newborns. Next, the newborns will be positioned according to the group they and then there will be a new temperature check.	Each newborn will be evaluated for only two weeks, being evaluated once a day, in the morning shift.
Primary	Blood pressure vital sign (mmHg) will be measured before and afterat different therapeutic positions of premature newborns under invasive mechanical ventilation.	Blood pressure (mmHg) will be checked on the multiparametric vital signs monitor with a value verified by means of a pressure cuff placed on the patient's upper limb, noted before the positioning of the premature newborns. Next, the newborns will be positioned according to the group and then there will be a new blood pressure check.	Each newborn will be evaluated for only two weeks, being evaluated once a day, in the morning shift.