Levosimendan Versus Milrinone in Off Pump CABG Surgery

Status Recruiting

Clinical Trial Summary

To compare the efficacy of Levosimendan versus Milrinone in supporting hemodynamics during off-pump coronary artery bypass grafting surgery in patients with low ejection fraction.

Clinical Trial Description

The major challenge during off-pump coronary artery bypass graft surgery is to maintain optimum hemodynamics by optimizing the intravascular volume and by using some inotropes. However, conventional inotropes such as beta‑agonists are associated with tachycardia and arrhythmia which increase myocardial oxygen demand.

Levosimendan is an inodilator which exerts its positive inotropic effect by enhancing the sensitivity of troponin C to calcium without increasing intracellular calcium concentration. Levosimendan also decreases the systemic vascular resistance, so, it increases the cardiac output without increasing myocardial oxygen consumption.

This study aims to compare the efficacy of Levosimendan versus Milrinone in supporting hemodynamics during off-pump coronary artery bypass grafting surgery in patients with low ejection fraction. ;

Study Design

Related Conditions & MeSH terms

Hemodynamics

Clinical Trial Details

NCT number	NCT03855579
Study type	Interventional
Source	Assiut University
Contact	Hany M. Osman, M.D.
Phone	+201002414591
Email	hanymeo@aun.edu.eg
Status	Recruiting
Phase	Phase 4
Start date	March 6, 2019
Completion date	September 10, 2019

View Details

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