Hemodynamic Changes of Tracheal Intubation With McCoy and Macintosh Laryngoscopes

Hemodynamic Rebound Clinical Trial

Official title:

Comparison of Hemodynamic Changes of Tracheal Intubation With McCoy and Macintosh Laryngoscopes

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05133375
• Other study ID #: 11112021
• Status: Completed
• Phase: N/A
• Start date: April 1, 2021
• Est. completion date: October 1, 2021

Study information

• Verified date: November 2021
• Source: CMH Jhelum
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

A total of 272 patients were randomly allocated into two groups, Patients in group A were treated with Macintosh laryngoscope and in groups B with McCoy laryngoscope was used for endotracheal intubation. Pulse and systolic blood pressure was recorded by non-invasive measures before laryngoscopy and at 30 seconds, 2 and 3minutes after intubation. All this information was recorded on a Pro forma.

Description:

After taking approval from hospital ethical committee, 272 patients who reported to Operation Theatre of CMH, Jhelum were selected for the study. Informed consent was obtained and patient demographic information (name, age, contact) was recorded. Patients were randomly divided in two equal groups by using lottery method. GROUP A: Where Macintosh laryngoscope was used for endotracheal intubation. GROUP B: Where McCoy laryngoscope was used for endotracheal intubation.

Before reporting to Operation theatre a detailed pre anesthesia assessment was done in all patients, all necessary laboratory investigations were collected. On OT table pulse and systolic blood pressure was checked by non-invasive method. 18G cannula was passed and ECG was attached. A pillow was placed under the head to obtain classical sniffing position for intubation. All the patients were pre medicated with injection midazolam 0.08mg/kg, injection nalbuphine 0.1 mg/kg, injection dexamethasone 0.08mg/kg and injection metoclopramide 0.1 mg/kg. Pre oxygenation was done with 100% oxygen for 3 mins. Induction was done with injection propofol2 mg/kg, muscle relaxation achieved with injection atracurium 0.5mg/kg. Laryngoscopy was started after 3 minutes by a qualified anesthetist. Pulse and systolic blood pressure was recorded by non-invasive measures before laryngoscopy and at 30 seconds, 2 and 3minutes after intubation. All this information was recorded on a Proforma.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 272
• Est. completion date: October 1, 2021
• Est. primary completion date: October 1, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• Both Male and Female

• Age between 18 to 70

• ASA I and II males and females.

• Malampatti I and II.

• Hemodynamically stable, no known ischemic heart disease and no history of hypertension.

• Nil per oral for at least 6 hours.

Exclusion Criteria:

• Non consenting patient.

• ASA III, IV or V patient.

• Malampati III or IV.

• Cervical instability

• Thyromental distance of less than 6cm, inter incisor distance of less than 3cm.

• Known case of hypertension and ischemic heart disease.

• Pregnant female.

• Body mass index of more than 30.

• Patients of oropharyngeal surgery.

• Unable to Intubate in less than 1 minute.

Related Conditions & MeSH terms

• Hemodynamic Rebound

Intervention

Procedure:
• Tracheal Intubation
Before reporting to Operation theatre, a detailed pre anesthesia assessment was done in all patients, all necessary laboratory investigations were collected. On OT table pulse and systolic blood pressure was checked by non-invasive method. 18G cannula was passed and ECG was attached. A pillow was placed under the head to obtain classical sniffing position for intubation. All the patients were pre medicated with injection midazolam 0.08mg/kg, injection nalbuphine 0.1 mg/kg, injection dexamethasone 0.08mg/kg and injection metoclopramide 0.1 mg/kg. Pre oxygenation was done with 100% oxygen for 3 mins. Induction was done with injection propofol2 mg/kg, muscle relaxation achieved with injection atracurium 0.5mg/kg. Laryngoscopy was started after 3 minutes by a qualified anesthetist. Pulse and systolic blood pressure was recorded by non-invasive measures before laryngoscopy and at 30 seconds, 2 and 3 minutes after intubation.

Locations

Country	Name	City	State
Pakistan	CMH	Jhelum	Punjab

Sponsors (1)

Lead Sponsor	Collaborator
CMH Jhelum

Country where clinical trial is conducted

Pakistan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Effect on the pulse of intubation with Macintosh and McCoy laryngoscope	To measure hemodynamic changes (i.e. pulse) of intubation with Macintosh and McCoy laryngoscope	After Laryngoscopy, pulse was recorded by non-invasive measures before laryngoscopy and at 30 seconds, 2 and 3 minutes after intubation.
Primary	Effect on the systolic blood pressure of intubation with Macintosh and McCoy laryngoscope	To measure hemodynamic changes (i.e. systolic blood pressure) of intubation with Macintosh and McCoy	After Laryngoscopy, systolic blood pressure was recorded by non-invasive measures before laryngoscopy and at 30 seconds, 2 and 3 minutes after intubation