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NCT05102058 Clinical Trial

Magnesium and Dexmedetomidine in Pheochromocytoma

Hemodynamic Instability Clinical Trial

Official title:
Magnesium and Dexmedetomidine Combination Reduces Sodium Nitroprusside Requirement in Laparoscopic Pheochromocytoma

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05102058
Other study ID # 2021/42
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 1, 2011
Est. completion date March 1, 2020

Study information
Verified date October 2021
Source Istanbul University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Anesthesia management of pheochromocytoma excision surgery is associated with severe hemodynamic fluctuations.The objective of this study was to compare the hypertensive episodes requiring sodium nitroprusside administration between the group treated with magnesium-dexmedetomidine and conventional group in pheochromocytoma.

Recruitment information / eligibility
Status Completed
Enrollment 108
Est. completion date March 1, 2020
Est. primary completion date March 1, 2020
Accepts healthy volunteers No
Gender All
Age group 18 Years to 75 Years
Eligibility Inclusion Criteria: - American Society of Anesthesiologists classification (ASA) 1-3 - high urinary catecholamine or metabolites - tumor sizes < 5 cm - body mass index (BMI) <35 kg/m2 Exclusion Criteria: - open surgery - bilateral masses - tumor larger than 5 cm - incomplete data

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Magnesium-Dexmedetomidine
Received oral 300 mg magnesium one week before surgery and magnesium-dexmedetomidine combination perioperatively

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Istanbul University

Outcome
Type Measure Description Time frame Safety issue
Primary Sodium nitroprusside (SNP) requirement intraoperative hypertensive episodes requiring SNP therapy intraoperative period
Secondary vasoactive therapy hemodynamic fluctuations (hypotension, tachycardia, severe hypertensive crisis) which needed vasoactive therapy. intraoperative period
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