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NCT05004545 Clinical Trial

Compare Hemodynamic Parameters of Propofol and Sevoflurane During CPB Time in Undergoing CABG to Avoid Lactate Level

Hemodynamic Instability Clinical Trial

Official title:
To Compare Hemodynamic Parameters of Propofol and Sevoflurane During Cardiopulmonary Bypass Time in Patients Undergoing Coronary Artery Bypass Graft (CABG) Surgery to Avoid Lactate Level.

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05004545
Other study ID # CPEIC-06
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date June 10, 2017
Est. completion date December 30, 2021

Study information
Verified date August 2021
Source Chaudhry Pervaiz Elahi Institute of Cardiology
Contact Kaneez Ume Farwa, FCPS
Phone +923356787214
Email farwatirmizi@hotmail.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Hemodynamic parameters and lactate level will be on CBP during CABG surgery patients.

Description:

Objective: To compare hemodynamic parameters of propofol and sevoflurane during cardiopulmonary bypass time in patients undergoing coronary artery bypass graft (CABG) surgery to avoid lactate level. Methods: One hundred and twenty six patients scheduled for CABG from May 2017 to May 2018 will be included in this study. Non probability consecutive sampling will be used. Patients will be divided in two groups, propofol will be given to group 1, and sevoflurane will be given to group 2. Age, clamp time, bypass time, mean arterial blood pressure on bypass machine and lactate level will be compared between two groups. SPSS version 24 will used and p value ≤ 0.05 will be considered as significant.

Recruitment information / eligibility
Status Recruiting
Enrollment 126
Est. completion date December 30, 2021
Est. primary completion date September 20, 2021
Accepts healthy volunteers No
Gender All
Age group 20 Years to 60 Years
Eligibility Inclusion Criteria: CABG Exclusion Criteria: Emergency surgery

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Propofol
Propofol infusion according to body weight will be compared with sevoflurane acording to MAC % to see the lactate level and hemodynamic parameters of CABG patients

Locations
Country Name City State
Pakistan Cardiac Surgery ICU Multan Punjab

Sponsors (1)
Lead Sponsor Collaborator
Chaudhry Pervaiz Elahi Institute of Cardiology

Country where clinical trial is conducted

Pakistan, 

Outcome
Type Measure Description Time frame Safety issue
Primary Lactate level will be measured during CPB for CABG patients to see the hemodynamics parameters The mean pre-cross clamp lactate level and post- rewarming lactate level will be calculated to see the effect of this on the CABG patients hemodynamics during CBP 06 months
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