The Effects of Esmolol on the Hemodynamic Response to Orotracheal Extubation

Hemodynamic Instability Clinical Trial

Official title:

The Effects of Esmolol on the Hemodynamic Response to Orotracheal Extubation: a Prospective, Randomized, Double-blind and Placebo-controlled Trial

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04264286
• Other study ID #: Esmolol and extubation
• Status: Recruiting
• Phase: Phase 4
• Start date: July 1, 2019
• Est. completion date: July 2020

Study information

• Verified date: February 2020
• Source: Hospital de Base
• Contact: Fabricio T Mendonça, MD, MSc
• Phone: 5561981882640
• Email: correiodofabricio[@]gmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Beta-blockers are useful tools for the prevention of hemodynamic instability in the manipulation of airways. The main objective of the present study is to evaluate the effectiveness of using esmolol in attenuating hemodynamic responses at the time of tracheal extubation, by assessing the incidence of tachycardia in relation to placebo.

Description:

The moment of extubation represents a critical period of anesthesia where important hemodynamic changes occur. These occur due to stimulation of the larynx, trachea and bronchi that generates an increased release of catecholamines. In high-risk patients, these hemodynamic changes can have serious consequences.

Many strategies have been used to control the hemodynamic response to airway manipulation during the period of intubation, but until today there is no standard therapy for this control during the period of extubation. Therefore, the investigators aim to study the use of beta-blockers in this context.

Beta-blockers are an attractive pharmacological strategy as they reduce the activation of the sympathetic nervous system proper at this time. Esmolol, due to its short half-life, can be an ideal tool to ensure better hemodynamic control.

There are few studies in the literature that study this drug during extubation, and there is no consensus on the best dose or method of administration for this moment.

Therefore, this study aims to evaluate the effectiveness of using esmolol in attenuating hemodynamic responses at the time of tracheal extubation, by assessing the incidence of tachycardia in relation to placebo.

This prospective, randomized, double-blind, placebo-controlled study aims to verify the hypothesis that esmolol reduces hemodynamic instability induced by tracheal extubation in surgical procedures at Base Hospital of the Federal District. The examiners responsible for patient assessment will not have access to the agents used.

Patients will be randomized through a randomly generated list. The examiner responsible for opening the envelope will make the draw, will include the patient in one of the groups, write down their data in the random list, prepare the syringe with the medication, and deliver it to the operating room so that the next examiners will not be aware of the administered drug.

Patients will receive standard general anesthesia and after the end of the surgical procedure, patients will be allocated the study drug (esmolol 2 mg/kg) or placebo group. All patients will receive sugammadex as a reversal of neuromuscular block and monitored appropriately.

The evolution of vital signs such as systolic blood pressure, mean heart rate, incidence and intensity of adverse events such as cough, bucking, bradycardia, tachycardia, hypertension, hypotension, vasopressor and anticholinergic consumption will be evaluated.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 80
• Est. completion date: July 2020
• Est. primary completion date: July 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• Patients aged between 18 and 60 years, electively scaled for surgery requiring general anesthesia.

• Physical State 1, 2 or 3 of the American Society of Anesthesiology (ASA)

Exclusion Criteria:

• Patients with cardiac disease

• Patients with renal disease

• Patients with liver disease

• Patient with lung disease

• Patients using beta blockers or calcium channel blockers

• Patients who refuse to participate in the study after presenting the informed consent form

Related Conditions & MeSH terms

• Beta Blocker
• Hemodynamic Instability

Intervention

Drug:
• Prophylactic esmolol
Patients will receive prophylactic esmolol after the end of the surgery
• Placebo
Patients will prophylactic placebo after the end of the surgery

Locations

Country	Name	City	State
Brazil	Hospital de Base do Distrito Federal	Brasília	DF

Sponsors (1)

Lead Sponsor	Collaborator
Hospital de Base

Country where clinical trial is conducted

Brazil, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Number of participants with adverse events as tachycardia	Intraoperative hemodynamic stability analysis through the incidence tachycardia	Through study completion, an average of 15 minutes (during awakening from anesthesia)