Hemodynamic Instability Clinical Trial
Official title:
The Effects of Lidocaine and Esmolol on Attenuation of Hemodynamic Response to Orotracheal Intubation: A Double-blind, Randomized, Clinical Trial
The present study aims to compare the hemodynamic response during laryngoscopy and orotracheal intubation using continuous infusion of lidocaine and esmolol in patients undergoing general anesthesia.
Esmolol is a selective beta-blocker of fast action that antagonizes beta-1 adrenergic
receptors. Venous lidocaine is the agent most used to attenuate the hemodynamic response to
laryngoscopy and intubation, in addition to cough reflex.
Objective: To compare the hemodynamic response during laryngoscopy and orotracheal intubation
using continuous infusion of lidocaine and esmolol.
Methods: Randomized, double masked clinical trial aims to compare the effect of esmolol and
lidocaine on orotracheal intubation. All patients will receive balanced general anesthesia.
One group (EG) will receive bolus esmolol of 1.5mg / kg in 10 min following by continuous
infusion at a rate of 0.1mg / kg / min. The lidocaine (LG) group will receive lidocaine bolus
of 1.5mg / kg in 10 min following by continuous infusion at a rate of 1.5mg / kg / h.
Data on hemodynamic changes, reaction to laryngoscopy, conditions at intubation and adverse
events will be evaluated.
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