Hemodynamic Instability Clinical Trial
Official title:
Evaluation of the Effect of Different Types of Extended Infusion Lines on Pulse Contour-based Measurements Based on the Arterial Pressure Signal
Hemodynamic monitoring of the critically-ill patients is increasingly performed using an
arterial pulse contour-based cardiac output device such as the proAQT system.
The aim of this study is to evaluate the effect of extending the pressure lines on the
arterial pressure wave and the calculated hemodynamic variables when using the proAQT system.
Hemodynamic continuous monitoring of critically-ill patients is increasingly performed with
minimally-invasive methods, such as the proAQT sensor (PULSION Medical Systems SE, Munich,
Germany).
The proAQT sensor calculates hemodynamic variables such as the cardiac output, stroke volume
(variation), pulse-pressure variation and systemic vascular resistance by pulse contour
analysis of the arterial pressure waveform using an arterial radial or femoral catheter. This
minimal invasive technique, also permits continuous beat-to-beat assessment.
In patients in who an arterial catheter is placed for clinical reasons, the hemodynamic
variables are continuously recorded. An extension line is coupled to a 3-way stopcock,
connected to the proAQT sensor. In a neutral position of the 3-way stopcock, the pressure
wave travels from the pressure sensor through the standard line. By turning the handle of the
stopcock the standard line is bypassed and the pressure wave travels through the extended
line.
The hemodynamic registration will be as follows:
- two minutes in the neutral position;
- two minutes with one type of extension line
- two minutes in the neutral position
- two minutes with a second type of extension line
- two minutes in neutral position
The arterial pressure curve and all calculated hemodynamic variables are electronically
registered.
The influence of two types of extension lines on the accuracy of the calculated hemodynamic
variables will be evaluated by comparing the variables measured in neutral position and
variables measured with the extended pressure lines. The changes in the calculated variables
will be correlated to possible arterial pressure waveform modifications and used to evaluate
different algorithms, which might be used to reconstruct the primary pressure wave.
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