Hemodialysis Complication Clinical Trial
Official title:
Effect of Alpha Lipoic Acid on the Clinical Outcome of Pediatric Patients Undergoing Hemodialysis
The goal of this clinical trial is to test alpha lipoic acid in children undergoing hemodialysis. The main questions it aims to answer are: - Will the use of alpha lipoic acid lower cardiovascular events in that population? - Is the incidence of those cardiovascular events linked to the oxidative stress and endothelial dysfunction in that population? - Will the drug cause side effects? Participants will: - take either one dose daily of 600mg tablet Alpha lipoic acid orally or a look-alike tablet containing no drug. - be monitored for the occurrence of cardiovascular events (stroke, angina, etc.) - be monitored for the occurrence of side effects - give blood samples for testing serum levels of E-selectin biomarker and superoxide dismutase enzyme - undergo clinical examinations (Echocardiogram, Duplex ultrasonography, Intima-Media-Thickness) Researchers will compare between the group taking alpha lipoic acid and the group taking the look-alike tablet.
A Double-Blinded, Paralleled, Randomized, Placebo-Controlled Clinical Trial will be conducted at the Pediatric Nephrology and Dialysis Unit, Children's Hospital, Ain Shams University, Cairo, Egypt to detect the efficacy of alpha lipoic acid in reducing cardiovascular events by reducing oxidative stress-mediated endothelial dysfunction in pediatric population on regular hemodialysis by assessment of: 1. E-selectin as an Endothelial biomarker 2. SOD as an Oxidative stress biomarker 3. Indicators of CVS dysfunction by; - Duplex ultrasonography - Echocardiogram with stress on Ejection Fraction - Intimal medial thickness 4. Occurrence of CVS events ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05980845 -
The Effect Nature Sounds and Music on Hemodialysis Patients
|
N/A | |
Recruiting |
NCT05020717 -
Retrospective Survey of Hyperkalemia in Hemodialysis
|
||
Recruiting |
NCT04046042 -
Virtual Reality Intradialysis: Last vs. First Part of the Session
|
N/A | |
Recruiting |
NCT04094038 -
The Effect of Intradialytic Parenteral Nutrition on Nutritional Status and Quality of Life in Hemodialysis Patients
|
Phase 4 | |
Completed |
NCT03311581 -
The Feasibility of Propofol TCI in Hemodialysis Patients Undergoing Arteriovenous Shunt Surgery
|
Phase 1 | |
Completed |
NCT05531175 -
REIKI APPLICATION PAIN, FATIGUE AND ITCHING IN HEMODIALYSIS PATIENTS
|
N/A | |
Completed |
NCT04057313 -
Coffee in Hemodialysis and Headache
|
N/A | |
Completed |
NCT03061552 -
Inferior Vena Cava Sonography in Hemodialysis Patients and Quality of Life
|
N/A | |
Completed |
NCT03251573 -
The Cohort Study of Cognitive Impairment in Chinese Hemodialysis Patients
|
||
Completed |
NCT03527680 -
Effect of Lactobacillus Rhamnosus on Serum Uremic Toxins in Hemodialysis
|
N/A | |
Completed |
NCT05568342 -
The Effect of Roy Adaptation-Based Nursing Intervention
|
N/A | |
Completed |
NCT04063423 -
Non- Clinical Coagulation Activation During Hemodialysis
|
||
Active, not recruiting |
NCT06203795 -
Dialysis Performance of the FX CorAL Membrane
|
N/A | |
Completed |
NCT04319328 -
Is Cefazolin, Ceftazidime and Ciprofloxacin Dosing Optimal in Hemodialysis Patients?
|
||
Completed |
NCT03627884 -
Outcomes of the Use of Sodium Bicarbonate (8.4%) Solution as a Catheter Lock Solution to Prevent Hemodialysis Catheter Loss Due to Lumen Clot Formation
|
Phase 4 | |
Completed |
NCT05132036 -
Lung Ultrasound Assessment of Fluid Overload in Haemodialysis Patients
|
N/A | |
Completed |
NCT03076528 -
An Innovative Virtually Supervised Exercise for Dialysis Patients
|
Phase 2 | |
Completed |
NCT06098443 -
Acupressure Versus Transcutaneous Electrical Nerve Stimulation on Pain and Quality of Life Intradialysis
|
N/A | |
Completed |
NCT04645121 -
Carbon Monoxide-based Rebreathing Method and Bioimpedance in Hemodialysis Patients
|
||
Recruiting |
NCT04127877 -
Bio Impedance-assisted Monitoring of Chronic Hemodialysis Patients
|
N/A |