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Hemodialysis.-Induced Hypotension Therapy for End Stage Kidney Disease — Hinder  

Hemodialysis Complication Clinical Trial

Official title:
Prevention of Dialysis-Induced Hypotension by Inhibiting Plasma Kallikrein

Clinical Trial Summary

Bradykinin is a potent vasodilator that is formed by the activation of the kallikrein-kinin system. We and others have shown that bradykinin increased during hemodialysis; however, the role of bradykinin in dialysis-induced hypotension (DIH) has not been evaluated. Preliminary results from a pilot clinical trial showed that bradykinin B2 receptor blockade with icatibant prevents excessive blood pressure during hemodialysis. Thus, in this study, we will test the overarching hypothesis that blockade plasma kallikrein with lanadelumab would ameliorate the reduction of blood pressure during hemodialysis in patients who are prone to DIH. For this purpose, we will conduct a parallel arm, double-blind placebo-controlled trial, using lanadelumab to evaluate the occurrence of

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05297786
Study type Interventional
Source Vanderbilt University Medical Center
Contact Jorge L Gamboa, M.D. Ph.D.
Phone 6153434176
Email jorge.gamboa@vumc.org
Status Recruiting
Phase Phase 2
Start date July 27, 2022
Completion date December 2024
View Details
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