Collateral Ligation in Failing Fistulas — CLiFF  

Hemodialysis Access Failure Clinical Trial

Official title: Prospective Randomized Evaluation of the Effect of Ligation of Venous Side Branches in Dialysis Arteriovenous Fistulas Presenting With Failure to Mature

Status Recruiting

Clinical Trial Summary

Arteriovenous fistulas (AVFs) for hemodialysis often fail to become usable due to failure to mature (FTM). The most common cause is narrowing of the artery or vein (stenosis). Another potential cause is the presence of collateral or side branch veins that steal blood flow from the main fistula channel. Some believe that occluding these veins might help maturation of those failing AVFs. To evaluate if this actually works, patients with FTM will be randomly assigned to side branch vein ligation (or not), and rates of AVF maturation of the two groups will be compared.

Clinical Trial Description

Arteriovenous fistulas (AVFs) for hemodialysis often fail to become usable due to failure to mature (FTM). The most common cause is stenosis of the artery or vein. Another potential cause is the presence of collateral or side branch veins that steal blood flow from the main fistula channel. The utility of ligating these veins to improve maturation of those failing AVFs is controversial. To evaluate this, 35 patients presenting for fistulograms for evaluation of AVFs with FTM, found to have side branch veins will be prospectively enrolled. After management of stenoses (if present), they will be randomly assigned to ligation of the venous side branches or not. Maturation rates for each group will be prospectively assessed. For patients assigned to the control group who have persistent failure to mature, a cross-over intervention will be performed and side branch ligation will be offered. ;

Related Conditions & MeSH terms

• Fistula
• Hemodialysis Access Failure

• NCT number: NCT03365089
• Study type: Interventional
• Source: Massachusetts General Hospital
• Contact: Zubin Irani, MD
• Phone: 617-643-0765
• Email: zirani@mgh.harvard.edu
• Status: Recruiting
• Phase: N/A
• Start date: May 14, 2018
• Completion date: March 31, 2020