Haemochromatosis:Phlebotomy Versus Erythrocytapheresis Therapy

Status Completed

Clinical Trial Summary

In this project we plan to evaluate the effectiveness of erythrocytapheresis against phlebotomy, both regarding the impact on the reduction in iron overload as well as reduction in patient "burden". Aspects of cost effectiveness will be included in the final analysis. Results of the study would allow decision-making based on Evidence Based Medicine on the "best" therapeutic options available for newly-diagnosed as well as existing primary hemochromatosis patients.

Clinical Trial Description

In this project we plan to evaluate the effectiveness of erythrocytapheresis against phlebotomy, both regarding the impact on the reduction in iron overload as well as reduction in patient "burden". Aspects of cost effectiveness will be included in the final analysis. The results of the study would allow decision-making based on Evidence Based Medicine on the "best" therapeutic options available for newly-diagnosed as well as existing primary hemochromatosis patients. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Hemochromatosis

Clinical Trial Details

NCT number	NCT00202436
Study type	Interventional
Source	Sanquin Research & Blood Bank Divisions
Contact
Status	Completed
Phase	Phase 3
Start date	October 2004
Completion date	September 2009

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT00199628` - Research Network for Neonatal Diseases Induced by Tissular Fetomaternal Alloimmunization
Completed	`NCT03654794` - Study of the Cellular Diffusion of Tacrolimus Across the Membrane of Mononuclear Cells
Terminated	`NCT00122980` - Stroke With Transfusions Changing to Hydroxyurea	Phase 3
Withdrawn	`NCT01892644` - Treatment of Iron Overload With Deferasirox (Exjade) in Hereditary Hemochromatosis and Myelodysplastic Syndrome	Phase 2
Not yet recruiting	`NCT01524757` - Proton Pump Inhibitors in the Prevention of Iron Reaccumulation in Patient With Hereditary Hemochromatosis	N/A
Completed	`NCT00349453` - Study Using Deferiprone Alone or in Combination With Desferrioxamine in Iron Overloaded Transfusion-dependent Patients	Phase 2
Recruiting	`NCT03743272` - Repeatability and Reproducibility of Multiparametric MRI
Recruiting	`NCT06137079` - "Iron Overload and Endocrinological Diseases"
Completed	`NCT00712738` - Oral Nifedipine to Treat Iron Overload	Phase 1
Completed	`NCT00001455` - Iron Overload in African Americans	N/A
Completed	`NCT00006312` - Hemochromatosis--Genetic Prevalence and Penetrance	N/A
Completed	`NCT00005559` - Statistical Basis for Hemochromatosis Screening	N/A
Recruiting	`NCT00509652` - Erythrocyte Apheresis Versus Phlebotomy in Hemochromatosis	N/A
Completed	`NCT00350662` - Study With Deferiprone and/or Desferrioxamine in Iron Overloaded Patients	Phase 3
Completed	`NCT00005541` - Hemochromatosis and Iron Overload Screening Study (HEIRS)	N/A
Completed	`NCT00000595` - Evaluation of Subcutaneous Desferrioxamine as Treatment for Transfusional Hemochromatosis	Phase 2
Completed	`NCT04631718` - MRI QSM Imaging for Iron Overload
Active, not recruiting	`NCT00007150` - Treatment of Hemochromatosis	Phase 2
Completed	`NCT00587535` - Evaluation of a New MR Pulse Sequence to Quantify Liver Iron Concentration	N/A
Enrolling by invitation	`NCT02025543` - Confounder-Corrected Quantitative MRI Biomarker of Hepatic Iron Content