Hematologic Malignancies Clinical Trial
Official title:
Exercise Capacity, Physical Activity Level and Quality of Life in Newly Diagnosed Hematologic Malignant Patients
Hematologic malignancies are neoplasms that affect the blood, bone marrow, and lymph nodes.
Hematological malignancies are the most common forms of leukemia, lymphoma, and myeloma, with
numerous subtypes. The general symptoms of leukemia are fatigue, increased susceptibility to
infection, bleeding, and the formation of bruises easily. Typical lymphoma symptoms are night
sweats and involuntary weight loss, recurrent fever, fatigue, and itching. Myeloma patients
often have bone pain, fatigue, anemia, hypercalcemia or infection symptoms.
Adverse effects of hematologic malignancies and treatments cause abnormality in physical
function and quality of life. Treatments such as chemotherapy, radiotherapy and hematopoietic
stem cell transplantation, which may have side effects on the body systems are used in early
or late period. The most common side effect due to chemotherapy is fatigue. Vomiting, weight
loss, anemia, depression, decreased aerobic capacity, loss of muscle strength, decreased
physical functioning and deterioration in the quality of life are indirect side effects seen
in patients.
In the literature, side effects of hematological malignancies have been investigated after
treatment in patients. However, no study investigated exercise capacity, quality of life,
physical activity level and pulmonary functions on newly diagnosed hematologic malignant
patients. Therefore, the investigators aimed to compare aforementioned outcomes in newly
diagnosed hematologic malignant patients and healthy controls.
According to sample size calculation 30 newly diagnosed hematologic malignant patients and 30 healthy individuals will be included. Before treatment submaximal exercise capacity, physical activity, quality of life, pulmonary functions, respiratory and peripheral muscle strength, respiratory muscle endurance, dyspnea and fatigue perception, anxiety and depression will be evaluated. Primary outcome measurements are exercise capacity, physical activity, quality of life, secondary outcomes are respiratory and peripheral muscle strength, respiratory muscle endurance, pulmonary functions, dyspnea and fatigue perception, anxiety and depression. ;
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