Hematologic Malignancies Clinical Trial
Official title:
Analysis of KIR+CD56+ T Cells and FcRg-CD56+CD3- NK Cells in Pediatric Allogeneic Hematopoietic Stem Cell Transplant Patients and Donors
Viral infections and reactivation during pediatric allogeneic hematopoietic stem cell
transplantation (HSCT) are a common occurrence and significantly contribute to
post-transplant morbidity and mortality. The risk is high due to prolonged periods of immune
deficiency while awaiting immune reconstitution post-transplant. Current strategies to reduce
complications from viral infections include prophylactic treatment, close monitoring for
viral infections and prompt treatment at the first sign of symptoms or increasing viral load.
However, the most definitive treatment for viral infections remains the host's cellular
defenses. Improved understanding of the immune systems response to viral infections may lead
to better treatment strategies.
This study is being done to explore the relationships between T-cells and NK cells (infection
fighting cells) and viral infections or reactivations in young allogeneic stem cell
transplant patients. The investigators will be looking at how these cells react and function
in young patients receiving allogeneic stem cell transplantation, as well as in healthy stem
cell donors.
PRIMARY OBJECTIVE:
- To explore the expansion patterns of KIR+CD56+ T-cells and FcRg-CD56+CD3- NK cells in
response to viral infection and reactivation in pediatric allogeneic hematopoietic stem
cell transplant (HSCT) patients.
SECONDARY OBJECTIVES:
- To describe the phenotype of KIR+CD56+ T-cells and FcRg-CD56+CD3- NK cells in pediatric
allogeneic HSCT patients and healthy donors.
- To describe the specificity and functional capacity of KIR+CD56+ T-cells against viral
antigens in both pediatric allogeneic HSCT patients and healthy donors.
- To describe the functional capacity of FcRg-CD56+CD3- NK cells against CMV-infected
cells in both pediatric allogeneic HSCT patients and healthy donors.
;
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