Monitoring Risks for Hematological Changes in Gas Station Workers

Hematologic Diseases Clinical Trial

Official title:

Monitoring Risks for Hematological Changes in Gas Station Workers

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05135078
• Other study ID #: Soh-Med-21-10-08
• Status: Not yet recruiting
• Start date: December 1, 2021
• Est. completion date: December 1, 2022

Study information

• Verified date: October 2021
• Source: Sohag University
• Contact: Sara T taha
• Phone: 01020858495
• Email: sara011097[@]med.sohag.edu.eg
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Gas station workers are exposed to carcinogenic substances.This increases risk of their exposure to hematological diseases such as lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), myelodysplastic syndromes (MDS), and myelogenous leukemia (AML), as well as different forms of non-Hodgkin's lymphoma (NHL) and multiple myeloma. Thus, the early identification of this condition between the gas station workers may prevent the hematological disease progression.

Description:

Gas station workers are exposed to carcinogenic substances.This increases risk of their exposure to hematological diseases such as lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), myelodysplastic syndromes (MDS), and myelogenous leukemia (AML), as well as different forms of non-Hodgkin's lymphoma (NHL) and multiple myeloma.

It is known that severe bone marrow dysplasia is frequently accompanied by early alterations in the immune system and in peripheral cell subsets.

The bone marrow injury by benzene metabolites is a strong predisposing factor in the pathogenesis of Benzene-induced hematopoietic disease .Thus, the early identification of this condition between the gas station workers may prevent the hematological disease progression.

The reactive metabolite of benzene, 1,4-benzoquinone (BQ) is suggested to be a key molecule of benzene-induced hematotoxicity and carcinogenicity as it cause abnormal accumulation of myeloid cells and precursors, which cause benzene induced cytopenia and myeloid dysplasia in humans.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 50
• Est. completion date: December 1, 2022
• Est. primary completion date: December 1, 2022
• Gender: Male
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• This study will be conducted on a group of gas station workers exposed to benzene for more than 3 years .

Exclusion Criteria:

• diagnosed gas station workers with blood malignancies .

• gas station workers exposed to benzene for less than 3 years .

Related Conditions & MeSH terms

• Hematologic Diseases

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Sohag University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The aim of study is to evaluate and monitor risks for hematological changes in gas station workers	The study will be conducted to a group of gas station workers exposed to benzene for more than 3 years, All workers will be subjected to complete blood count .	within 6 months .
Primary	The aim of study is to evaluate and monitor risks for hematological changes in gas station workers	The study will be conducted to a group of gas station workers exposed to benzene for more than 3 years, All workers will be subjected to liver function tests as alanine transaminase (ALT) measured by IU/L, aspartate transaminase (AST) measured by IU/L, total protein measured by gm/dl, albumin measured by g/dl and bilirubin measured by mg/dl.	within 6 months .
Primary	The aim of study is to evaluate and monitor risks for hematological changes in gas station workers	The study will be conducted to a group of gas station workers exposed to benzene for more than 3 years, All workers will be subjected to renal function tests as serum creatinine measured by mg/dl, serum urea measured by mg/dl and uric acid measured by mg/dl .	within 6 months .
Primary	The aim of study is to evaluate and monitor risks for hematological changes in gas station workers	The study will be conducted to a group of gas station workers exposed to benzene for more than 3 years, All workers will be subjected to CD45, CD34, HLA-DR, CD33, CD13, CD19, CD22, CD2, CD3, CD5, CD7, CD4, CD8, CD10, CD16 and CD65 measured by flowcytometry	within 6 months .
Primary	The aim of study is to evaluate and monitor risks for hematological changes in gas station workers	The study will be conducted to a group of gas station workers exposed to benzene for more than 3 years, All workers will be subjected to ESR (Erythrocyte sedimentation rate) measured by mm .	within 6 months ,