Monitoring Risks for Hematological Changes in Gas Station Workers

Status Not yet recruiting

Clinical Trial Summary

Clinical Trial Description

Gas station workers are exposed to carcinogenic substances.This increases risk of their exposure to hematological diseases such as lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), myelodysplastic syndromes (MDS), and myelogenous leukemia (AML), as well as different forms of non-Hodgkin's lymphoma (NHL) and multiple myeloma. It is known that severe bone marrow dysplasia is frequently accompanied by early alterations in the immune system and in peripheral cell subsets. The bone marrow injury by benzene metabolites is a strong predisposing factor in the pathogenesis of Benzene-induced hematopoietic disease .Thus, the early identification of this condition between the gas station workers may prevent the hematological disease progression. The reactive metabolite of benzene, 1,4-benzoquinone (BQ) is suggested to be a key molecule of benzene-induced hematotoxicity and carcinogenicity as it cause abnormal accumulation of myeloid cells and precursors, which cause benzene induced cytopenia and myeloid dysplasia in humans. ;

Study Design

Related Conditions & MeSH terms

Hematologic Diseases

Clinical Trial Details

NCT number	NCT05135078
Study type	Observational
Source	Sohag University
Contact	Sara T taha
Phone	01020858495
Email	sara011097@med.sohag.edu.eg
Status	Not yet recruiting
Phase
Start date	December 1, 2021
Completion date	December 1, 2022

View Details

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