Hematologic Diseases Clinical Trial
Official title:
Response to Chimeric Antigen Receptor (CAR)-T Cells Therapy in Patients With Hematologic Malignancies (Lymphoma, Acute Lymphoblastic Leukemia, Multiple Myeloma) Depending on Tumor Characteristics
Immunotherapy with Chimeric Antigen Receptor (CAR) T Cells, T cells whose receptor has been
genetically modified, is based on improving the immune response against the tumor. This
approach is promising for patients with hematologic malignancies refractory to chemotherapy.
Despite impressive results, too many patients are relapsing. The reasons for the relapse,
after the injection of CAR T cells, need to be explored. In this context of newly introduced
therapeutics, it is essential to better understand the factors associated with the response
to treatment with CAR T Cells, especially the characteristics of the tumor and its
microenvironment.
The objective of this study is to understand the role of tumor biology, and its
microenvironment, in the response to CAR-T Cells therapy in patients with hematologic
malignancies
n/a
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