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NCT00179946 Clinical Trial

HLA Matching - Unrelated Umbilical Cord Blood Transplantation

Hematologic Diseases Clinical Trial

Official title:
Impact of HLA Matching on Outcome in Pediatric Patients Undergoing Unrelated Umbilical Cord Blood Transplantation.

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00179946
Other study ID # BMT 0603 HLA
Secondary ID
Status Completed
Phase
First received
Last updated
Start date June 2003
Est. completion date April 2006

Study information
Verified date July 2018
Source Ann & Robert H Lurie Children's Hospital of Chicago
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The aim of this protocol is to clarify the role of HLA matching in unrelated umbilical cord blood (UCB) transplantation and to identify the level of HLA matching required assuring successful outcome of unrelated UCB transplantation.

Description:

The aim of this protocol is to clarify the role of HLA matching in unrelated umbilical cord blood (UCB) transplantation and to identify the level of HLA matching required assuring successful outcome of unrelated UCB transplantation.

The study will answer the following questions:

1. Is HLA matching beneficial to unrelated UCB transplantation?

2. Which HLA loci, HLA-A, B, C, DRB1, or BQB1 is/are important to math, or alternatively to mismatch, to improve graft survival?

3. Which HLA loci, HLA-A, B, C, DRB1, or BQB1 mismatches is/are "permissive mismatches" or well tolerated mismatches?

4. What level of typing resolution (low, intermediate, or hgh) is required to perform patient/donor H:A matching?

By studying the cells and blood of donors and recipients, we may learn more about improving the tissue matching between unrelated donors and their recipients. Also, we hope to learn if an additional level of matching testing improves the results of the transplant treatment. Increasing knowledge about tissue matching could result in the improved long-term survival of cord blood transplant recipients.

Recruitment information / eligibility
Status Completed
Enrollment 30
Est. completion date April 2006
Est. primary completion date April 2006
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria:

- Pediatric Patients undergoing an unrelated umbilical cord blood transplantation.

Exclusion Criteria:

- Refusal to participate in study.

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• HLA typing

Locations
Country Name City State
United States Ann & Robert H Lurie Children's Hospital of Chicago Chicago Illinois

Sponsors (1)
Lead Sponsor Collaborator
Ann & Robert H Lurie Children's Hospital of Chicago

Country where clinical trial is conducted

United States, 

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