Tailored H. Pylori Eradication Based on Clarithromycin Resistance

Status Completed

Clinical Trial Summary

The investigators investigated the point mutations in the 23S rRNA genes of patients infected with clarithromycin-resistant H. pylori and compared the H. pylori eradication rates based on the identified clinically significant point mutations.

Clinical Trial Description

Sequencing-based detection of point mutations identified four mutations that were considered clinically significant (A2142G, A2142C, A2143G, A2143C), while all the other mutations were considered clinically insignificant.

Participants who did not have point mutations related to clarithromycin resistance and/or had clinically insignificant point mutations were treated with PAC (proton pump inhibitor, amoxicillin, clarithromycin) for 7 days, while participants with clinically significant point mutations were treated with PAM (proton pump inhibitor, amoxicillin, metronidazole) for 7 days. H. pylori eradication rates were compared between the two groups. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03884348
Study type	Observational
Source	Kangdong Sacred Heart Hospital
Contact
Status	Completed
Phase
Start date	January 1, 2017
Completion date	December 31, 2018

View Details

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