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NCT03057171 Clinical Trial

A Study on the Gastrointestinal Disease and Helicobacter Pylori Controlled Long Non-coding RNA

Helicobacter Pylori Infection Clinical Trial

Official title:
A Study on the Gastrointestinal Disease and Helicobacter Pylori Controlled Long Non-coding RNA

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT03057171
Other study ID # 4-2015-0146
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date May 2015
Est. completion date April 2020

Study information
Verified date March 2019
Source Yonsei University
Contact Sang Kil Lee, MD
Phone 82-2-2228-1996
Email sklee@yuhs.ac
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Helicobacter pylori (H.pylori) is a major human pathogenic bacterium in gastric mucosa which is linked to the development of gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma and gastric cancer. However the regulatory mechanism of H.pylori-induced immune response is not clear. Long non-coding RNA (lncRNA) has recently emerged as key post-transcriptional regulators of gene expression, differentiation. The investigators had a preliminary results which THRIL (TNFα and hnRNPL related immunoregulatory lincRNA) and PACER(p50-associated COX-2 extragenic RNA) played a potential role in H.pylori induced inflammatory cascade. However, there wasn't a previous study about expression of THRIL, PACER in a human tissue. Therefore, the investigators aimed to evaluate the expression of THRIL, PACER in patients with gastrointestinal disease according to H.pylori infection.

Recruitment information / eligibility
Status Recruiting
Enrollment 50
Est. completion date April 2020
Est. primary completion date April 2020
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 19 Years and older
Eligibility Inclusion Criteria:

1. Over 19 years old

2. Patients with gastric ulcer

3. Patients with duodenal ulcer

4. Patients with stomach cancer

5. Patients with gastrointestinal discomfort symptoms

Exclusion Criteria:

1. Patients who has done helicobacter pylori eradication

2. Patients who has undergone gastrectomy

3. Patients who has undergone endoscopic submucosal dissection

4. Patients with active upper gastrointestinal bleeding

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Korea, Republic of Yonsei university College of Medicine Seoul

Sponsors (1)
Lead Sponsor Collaborator
Yonsei University

Country where clinical trial is conducted

Korea, Republic of, 

Outcome
Type Measure Description Time frame Safety issue
Primary Expression of THRIL, PACER Expression of THRIL, PACER according to Helicobacter pylori infection by Real-time aRT-PCR Within 2 weeks after EGD
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