Helicobacter Pylori Infection Clinical Trial
Official title:
Usefulness of Antimicrobial Susceptibility in the Eradication of Helicobacter Pylori
Due to the high rate of resistance to clarithromycin in our area the investigators proposed an study to assess the need of antibiogram previous to the empirical OCA 10 treatment, in order to improve the rate of eradication.
Usefulness of antimicrobial susceptibility in the eradication of Helicobacter pylori
PURPOSE
Background:
- The rate of eradication of Helicobacter pylori with standard triple therapy (OCA:
omeprazole + clarithromycin + amoxicillin) in our area is less than the expected
according to the III Maastricht III consensus. However, the current guidelines
recommend the use of this therapy.
- According to the Maastricht III consensus, in populations with high rates of
clarithromycin resistance (15-20%) another therapy should be considered, or
alternatively, testing antimicrobial susceptibility of the H. pylori prior to
treatment.
Objectives:
- To clarify the real rate of eradication with OCA therapy with and without antimicrobial
susceptibility in our area (with high rate of resistance to clarythromycin).
- To study which is the diagnostic-therapeutic strategy more cost-effective for the
treatment of H. pylori.
Design:
- Participants will be screened with a full medical history.
- Participants will aleatory receive OCA therapy empirically, or after antimicrobial
susceptibility test if there is no resistance to clarythromycin, for ten days.
- In all cases the eradication of H. pylori will be checked by 13C urea breath test (UBT)
in 8 weeks after the therapy have been finished.
- All the adverse event of the therapy will be reported.
;
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