Heavy Smoking Clinical Trial
Cigarette smoking is a major public health problem causing significant morbidity and
mortality. Yet, smoking cessation therapies are often ineffective at helping smokers break
their addiction.
The mesolimbic dopaminergic reward system plays a crucial role in mediating the reinforcing
effects of nicotine. Recently, acute high frequency repetitive transcranial magnetic
stimulation (rTMS) of frontal brain regions has been shown to efficiently modulate the
mesolimbic dopamine systems in both animals and humans. For this reason, we investigated
whether 10 high-frequency (10Hz) rTMS treatments over the left dorsolateral prefrontal
cortex can help people to withdraw smoking in comparison to placebo rTMS.
Smokers seeking to quit are recruited through newspaper advertisements. Participants were
randomized to 10 days of either real or placebo high frequency rTMS.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
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